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Titolo:
Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol
Autore:
Burggraaf, J; Lalezari, S; Emeis, JJ; Vischer, UM; de Meyer, PHEM; Pijl, H; Cohen, AF;
Indirizzi:
Ctr Human Drug Res, NL-2333 CL Leiden, Netherlands Ctr Human Drug Res Leiden Netherlands NL-2333 CL CL Leiden, Netherlands TNO, Gaubius Inst, Prevent & Hlth, Leiden, Netherlands TNO Leiden Netherlands aubius Inst, Prevent & Hlth, Leiden, Netherlands HCU Geneva, Geneva, Switzerland HCU Geneva Geneva SwitzerlandHCU Geneva, Geneva, Switzerland Leiden Univ, Ctr Med, Dept Internal Med, Leiden, Netherlands Leiden Univ Leiden Netherlands , Dept Internal Med, Leiden, Netherlands
Titolo Testata:
THYROID
fascicolo: 2, volume: 11, anno: 2001,
pagine: 153 - 160
SICI:
1050-7256(200102)11:2<153:EFIPWH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; FACTOR-VIII ACTIVITY; THYROID-HORMONE; GRAVES-DISEASE; PLASMINOGEN-ACTIVATOR; ATRIAL-FIBRILLATION; GENE-EXPRESSION; PLASMA; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Burggraaf, J Ctr Human Drug Res, Zernikedreef 10, NL-2333 CL Leiden, Netherlands Ctr Human Drug Res Zernikedreef 10 Leiden Netherlands NL-2333 CL
Citazione:
J. Burggraaf et al., "Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol", THYROID, 11(2), 2001, pp. 153-160

Abstract

Hyperthyroidism is associated with a higher incidence of arterial thromboembolism; increasing age, atrial fibrillation, and mitral valve abnormalities are risk factors. However, the contribution of endogenous coagulation parameters is unclear. Because thyroid hormone influences receptor and transcription factors, it can be expected that it will influence proteins involvedin coagulation processes synthetised in many cells. Fourteen hyperthyroid patients were studied untreated, after 1 week of treatment with propranolol, and after therapeutic treatment with thiamazol. Fourteen matched controls were used for comparison. On each occasion, endothelial marker proteins, coagulation/fibrinolysis factors, and inflammatory (liver) markers were measured. Excess thyroid hormone was associated with elevated levels of most endothelium-associated proteins. In addition, plasma fibronectin and fibrinogen were increased, while plasminogen was decreased. No evidence was found that hyperthyroidism was associated with coagulation/fibrinolysis activation, or with increased levels of the inflammation markers interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) or C-reactive protein (CRP). Propranolol treatment only lowered the von Willebrand factor propeptide, and slightly increased plasminogen. Treatment with thiamazol returned all parameters to normal. Hyperthyroidism increased the plasma levels of most endothelial marker proteins, and of some liver-synthetized proteins. No evidence for coagulation/fibrinolysis activation was found. However, it appears that endothelial activation, which is indicative of a procoagulant state, is present in hyperthyroidism. This may explain the association between hyperthyroidismand thromboembolism especially if other risk factors are present. von Willebrand factor II (vWF:Ag-II) levels may be suitable markers to evaluate acute changes in endothelial function because this parameter responds more rapidly to changes in endothelial function than other factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:46:56