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Titolo:
Nuclear localization of epidermal growth factor and epidermal growth factor receptors in human thyroid tissues
Autore:
Marti, U; Ruchti, C; Kampf, J; Thomas, GA; Williams, ED; Peter, HJ; Gerber, H; Burgi, U;
Indirizzi:
Univ Hosp Bern, Endocrine & Diabet Div, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 t Div, CH-3010 Bern, Switzerland Univ Hosp Bern, Dept Clin Chem, Bern, Switzerland Univ Hosp Bern Bern Switzerland Bern, Dept Clin Chem, Bern, Switzerland Univ Hosp Bern, Div Med, Bern, Switzerland Univ Hosp Bern Bern Switzerland v Hosp Bern, Div Med, Bern, Switzerland Univ Hosp Bern, Dept Pathol, Bern, Switzerland Univ Hosp Bern Bern Switzerland sp Bern, Dept Pathol, Bern, Switzerland Univ Cambridge, Strangeways Res Lab, Thyroid Carcinogenesis Grp, Cambridge, England Univ Cambridge Cambridge England Carcinogenesis Grp, Cambridge, England
Titolo Testata:
THYROID
fascicolo: 2, volume: 11, anno: 2001,
pagine: 137 - 145
SICI:
1050-7256(200102)11:2<137:NLOEGF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTACT RAT HEPATOCYTES; FACTOR EGF RECEPTOR; MESSENGER-RNA; FACTOR-ALPHA; CONSTITUTIVE INTERNALIZATION; THYROXINE INCREASES; CELL-PROLIFERATION; LIVER-REGENERATION; NODULAR GOITER; NUDE-MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Marti, U Univ Hosp Bern, Endocrine & Diabet Div, Freiburgstasse 15, CH-3010 Bern, Switzerland Univ Hosp Bern Freiburgstasse 15 Bern Switzerland CH-3010 erland
Citazione:
U. Marti et al., "Nuclear localization of epidermal growth factor and epidermal growth factor receptors in human thyroid tissues", THYROID, 11(2), 2001, pp. 137-145

Abstract

Epidermal growth factor (EGF) has widespread growth effects, and in some tissues proliferation is associated with the nuclear localization of EGF andepidermal growth factor receptor (EGFR). Ln the thyroid, EGF promotes growth but differs from thyrotropin (TSH) in inhibiting rather than stimulatingfunctional parameters. We have therefore studied the occurrence and cellular distribution of EGF and EGFR in normal thyroid, in Graves' disease, where growth is mediated through the thyrotropin receptor (TSHR), and in a variety of human thyroid tumors. In the normal gland the staining was variable,but largely cytoplasmic, for both EGF and EGFR. In Graves' disease there was strong cytoplasmic staining for both EGF and EGFR, with frequent positive nuclei. Nuclear positivity for EGF and particularly for EGFR was also a feature of both follicular adenomas and follicular carcinomas. Interestinglynuclear staining was almost absent in papillary carcinomas. These findingsdocument for the first time the presence of nuclear EGF and EGFR in thyroid. Their predominant occurrence in tissues with increased growth (Graves' disease, follicular adenoma, and carcinoma) may indicate that nuclear EGF and EGFR play a role in growth regulation in these conditions. The absence ofnuclear EGF and EGFR in papillary carcinomas would suggest that the role played by EGF in growth control differs between papillary carcinoma and follicular adenomas/carcinomas of the thyroid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:17:58