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Titolo:
Solid phase synthesis of benzothiazolyl compounds
Autore:
Mourtas, S; Gatos, D; Barlos, K;
Indirizzi:
Univ Patras, Dept Chem, Patras, Greece Univ Patras Patras GreeceUniv Patras, Dept Chem, Patras, Greece
Titolo Testata:
TETRAHEDRON LETTERS
fascicolo: 11, volume: 42, anno: 2001,
pagine: 2201 - 2204
SICI:
0040-4039(20010311)42:11<2201:SPSOBC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSE REDUCTASE INHIBITORS; MAO-A INHIBITOR; 2-(4-AMINOPHENYL)BENZOTHIAZOLES; 2-ARYLBENZOTHIAZOLES; MECHANISM; AGENTS; POTENT;
Keywords:
benzothiazoles; benzothiazole equivalent; solid phase synthesis; trityl resin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Barlos, K Univ Patras, Dept Chem, Patras, Greece Univ Patras Patras Greece v Patras, Dept Chem, Patras, Greece
Citazione:
S. Mourtas et al., "Solid phase synthesis of benzothiazolyl compounds", TETRAHEDR L, 42(11), 2001, pp. 2201-2204

Abstract

2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)- and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acylaminobenzenethiols were cleaved from the resin by treatment with trifluoroacetic acid solutions in dichloromethane. The 2-N-acyl-aminobenzenethiols released from the resin were cyclised to the corresponding 2-substituted benzothiazoles, by standing in a solution of dithiothreitolin DMF or methanol for 1-3 h at room temperature. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:49:45