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Titolo:
Universal Rink-isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines
Autore:
Chen, JJ; Golebiowski, A; McClenaghan, J; Klopfenstein, SR; West, L;
Indirizzi:
Procter & Gamble Pharmaceut, Combinatorial Chem Grp, Mason, OH 45040 USA Procter & Gamble Pharmaceut Mason OH USA 45040 m Grp, Mason, OH 45040 USA
Titolo Testata:
TETRAHEDRON LETTERS
fascicolo: 12, volume: 42, anno: 2001,
pagine: 2269 - 2271
SICI:
0040-4039(20010318)42:12<2269:URRAFT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE SYNTHESIS; DEALKYLATION; ISOCYANIDE; CHLORIDES; ACCESS;
Keywords:
combinatorial synthesis; solid-phase synthesis; heterocyclic chemistry; multi-component reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, JJ Procter & Gamble Pharmaceut, Combinatorial Chem Grp, 8700 Mason MontgomeryRd, Mason, OH 45040 USA Procter & Gamble Pharmaceut 8700 Mason Montgomery Rd Mason OH USA 45040
Citazione:
J.J. Chen et al., "Universal Rink-isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines", TETRAHEDR L, 42(12), 2001, pp. 2269-2271

Abstract

Rink resin was converted to isonitrile resin after formylation with HCO2H/diisopropylcarbodiimide followed by POCl3/diisopropylethylamine dehydration. This polymer-supported isonitrile was then employed in the multi-component synthesis of imidazo[1,2-a]pyridines. The resin-bound imidazo[1,2-a]pyridine was acylated and spontaneously released by acyl chloride treatment in dichloroethane. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:52:18