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Titolo:
D-2 but not D-3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: Influence of withdrawal period
Autore:
Joyce, JN;
Indirizzi:
Thomas H Christopher Ctr Parkinsons Dis Res, Sun Hlth Res Inst, Sun City, AZ 85351 USA Thomas H Christopher Ctr Parkinsons Dis Res Sun City AZ USA 85351 351 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 40, anno: 2001,
pagine: 137 - 144
SICI:
0887-4476(200105)40:2<137:DBNDRA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; DOPAMINE-RECEPTOR; NUCLEUS-ACCUMBENS; RAT STRIATUM; STRIATOPALLIDAL NEURONS; DIFFERENTIAL REGULATION; GENE-EXPRESSION; HUMAN FOREBRAIN; UP-REGULATION; D2 RECEPTORS;
Keywords:
striatum; caudate-putamen; nucleus accumbens; islands of Calleja; limbic; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Joyce, JN Thomas H Christopher Ctr Parkinsons Dis Res, Sun Hlth Res Inst, Sun City, AZ 85351 USA Thomas H Christopher Ctr Parkinsons Dis Res Sun City AZ USA 85351
Citazione:
J.N. Joyce, "D-2 but not D-3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: Influence of withdrawal period", SYNAPSE, 40(2), 2001, pp. 137-144

Abstract

Previous postmortem studies have identified divergent alterations in D-2 and D-3 receptors in schizophrenia but those results cannot be interpreted without further understanding of whether antipsychotic regulation of the D-3receptor is different from that of the D-2 receptor. Depot parenteral administration of haloperidol decanoate was utilized to achieve consistent highlevels in rat brain for 9 months with 2-month withdrawal or 11 months with48-h withdrawal and compared to vehicle control and acute haloperidol (48-h) treatment groups. Autoradiographic means for measuring levels of D-2 ([H-3]-spiperone) and D-3 receptors ([I-125]trans 7-OH-PIPAT) and of D-3 mRNA by in situ hybridization histochemistry in rat caudate-putamen, nucleus accumbens, islands of Calleja, and olfactory tubercle determined that there were significant group differences for regulation of D-2 receptor. Chronic haloperidol for 9 or 11 months elevated D-2 but not D-3 receptors or D-3 mRNAin all regions measured. Acute haloperidol treatment had no significant effects for any measure. Treatment for 9 months with a 2-month withdrawal resulted in a persistent increase in D-2 receptors that was greater than that observed in the 11 months with 48-h withdrawal. This effect was most noticeable in the olfactory tubercle. These data confirm previous findings that short- or long-term haloperidol treatment leads to elevations in D-2 but notD-3 receptors or D-3 mRNA, and long-term withdrawal from chronic haloperidol does not lead to elevations in D-3 receptors or D-3 mRNA. This suggests that an elevation in D-3 receptors identified at postmortem in schizophrenics withdrawn from antipsychotics is not the result of the previous drug history [Gurevich et al. (1997) Arch Gen Psychiatry 54:225-232]. Synapse 40: 137-144, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:50:19