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Titolo:
Long-term impairment of anterograde axonal transport along fiber projection originating in the rostral raphe nuclei after treatment with fenfluramineor methylenedioxymethamphetamine
Autore:
Callahan, BT; Cord, BJ; Ricaurte, GA;
Indirizzi:
Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21224 USA Johns HopkinsMed Inst Baltimore MD USA 21224 ol, Baltimore, MD 21224 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 40, anno: 2001,
pagine: 113 - 121
SICI:
0887-4476(200105)40:2<113:LIOAAT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALVULAR HEART-DISEASE; SEROTONIN UPTAKE SITES; RAT-BRAIN; (+/-)-3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; TRYPTOPHAN-HYDROXYLASE; DL-FENFLURAMINE; TIME-COURSE; NEUROTOXICITY; DEXFENFLURAMINE; TERMINALS;
Keywords:
anterograde transport; fenfluramine; methylenedioxymethamphetamine; neurotoxicity; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Ricaurte, GA Johns Hopkins Med Inst, Dept Neurol, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA Johns Hopkins Med Inst 5501 Hopkins Bayview Circle Baltimore MD USA 21224
Citazione:
B.T. Callahan et al., "Long-term impairment of anterograde axonal transport along fiber projection originating in the rostral raphe nuclei after treatment with fenfluramineor methylenedioxymethamphetamine", SYNAPSE, 40(2), 2001, pp. 113-121

Abstract

To further evaluate the serotonin (5-HT) neurotoxic potential of substituted amphetamines, we used tritiated proline to examine anterograde transportalong ascending axonal projections originating in the rostral raphe nucleiof animals treated 3 weeks previously with(+/- )fenflurammne (FEN, 10 mg/kg, every 2 h x 4 injections; i.p.) or (+/- )3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, twice daily for 4 days; s.c.). The documented 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT, 75 mug; ICV; 30 min after pretreatment with pargyline, 50 mg/kg; i.p., and desipramine 25 mg/kg; i.p.), served as a positive control. Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). Prior treatment with FEN or MDMA led to marked reductions in anterograde transport of labeled material to various forebrain regions known to receive 5-HT innervation. These reductions were associated with lasting decrements in 5-HT axonal markers. In general, decreases in axonal transport were less pronounced than those in 5-HT and 5-HIAA. However, identical changes were observed after 5,7-DHT. These results further indicate that FEN and MDMA, like 5,7-DHT, are 5-HT neurotoxins. Synapse 40:113-121, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:34:00