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Titolo:
Acute and repeated administration of the selective 5-HT2A receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons:An in vivo electrophysiological study
Autore:
Minabe, Y; Hashimoto, K; Watanabe, K; Ashby, CR;
Indirizzi:
St Johns Univ, Coll Pharm & Allied Hlth Profess, Dept Pharmaceut Sci, Jamaica, NY 11439 USA St Johns Univ Jamaica NY USA 11439 Pharmaceut Sci, Jamaica, NY 11439 USA Takamatsu Prefectural Hosp, Dept Psychiat, Takamatsu, Ishikawa, Japan Takamatsu Prefectural Hosp Takamatsu Ishikawa Japan tsu, Ishikawa, Japan Natl Inst Neurosci, Kodaira, Tokyo, Japan Natl Inst Neurosci Kodaira Tokyo Japan t Neurosci, Kodaira, Tokyo, Japan Yoshitomi Pharmaceut Ind Ltd, Iruma, Saitama, Japan Yoshitomi Pharmaceut Ind Ltd Iruma Saitama Japan , Iruma, Saitama, Japan Univ Tokyo, Dept Neuropsychiat, Bunkyo Ku, Tokyo, Japan Univ Tokyo TokyoJapan kyo, Dept Neuropsychiat, Bunkyo Ku, Tokyo, Japan
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 40, anno: 2001,
pagine: 102 - 112
SICI:
0887-4476(200105)40:2<102:AARAOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; CENTRAL-NERVOUS-SYSTEM; DEPOLARIZATION BLOCK; SUBCELLULAR-DISTRIBUTION; PREFRONTAL CORTEX; MESSENGER-RNA; RAT; HALOPERIDOL; MDL-100,907; CLOZAPINE;
Keywords:
electrophysiology; M100907; ventral tegmental area; substantia nigra pars compacta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, CR St Johns Univ, Coll Pharm & Allied Hlth Profess, Dept PharmaceutSci, 8000Utopia Pkwy, Jamaica, NY 11439 USA St Johns Univ 8000 Utopia PkwyJamaica NY USA 11439 NY 11439 USA
Citazione:
Y. Minabe et al., "Acute and repeated administration of the selective 5-HT2A receptor antagonist M100907 significantly alters the activity of midbrain dopamine neurons:An in vivo electrophysiological study", SYNAPSE, 40(2), 2001, pp. 102-112

Abstract

We examined the effect of the acute and repeated administration of M100907(formerly MDL 100907), a selective 5-HT2A receptor antagonist, on spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) of rats. This was accomplished using in vivo, extracellular single unit recording. The i.v. administration of M100907 (0.01-0.64 mg/kg) did not significantly alter the basal firing rate orpattern of spontaneously active SNC and VTA DA neurons. A single injectionof either 0.01 or 0.03 mg/kg i.p. of M100907 did not significantly alter the number of spontaneously active DA neurons in either the SNC or VTA areas. However, 0.1 mg/kg i.p. of M100907 significantly increased the number of spontaneously active SNC and VTA DA neurons compared to vehicle-treated animals. A single injection of all doses of M100907 significantly decreased the degree of bursting in VTA DA neurons, whereas the 0.1 mg/kg dose increased the degree of bursting in SNC DA neurons. The repeated administration (one injection per day for 21 days) of 0.03 and 0.1 mg/kg i.p. of M100907 produced a significant decrease in the number of spontaneously active SNC and VTA DA neurons compared to vehicle-treated animals. The repeated administration of M100907 did not significantly alter the firing pattern of VTA DA neurons but significantly altered the firing pattern of SNC DA neurons. The results of this study indicate that M100907 administration alters the activity of midbrain DA neurons in anesthetized rats. Synapse 40:102-112, 2001, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 25/01/20 alle ore 19:40:33