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Titolo:
Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: Stromal cells as BMT-Facilitating cells
Autore:
Fan, TX; Hisha, H; Jin, TN; Yu, CZ; Lian, ZX; Guo, SB; Cui, YZ; Feng, B; Yang, GX; Li, Q; Ikehara, S;
Indirizzi:
Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 5708506, Japan Kansai MedUniv Moriguchi Osaka Japan 5708506 guchi, Osaka 5708506, Japan Kansai Med Univ, Transplantat Ctr, Moriguchi, Osaka 5708506, Japan Kansai Med Univ Moriguchi Osaka Japan 5708506 guchi, Osaka 5708506, Japan
Titolo Testata:
STEM CELLS
fascicolo: 2, volume: 19, anno: 2001,
pagine: 144 - 150
SICI:
1066-5099(2001)19:2<144:SABMT(>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE-HYPERSENSITIVITY; HEMATOPOIETIC STEM-CELLS; AUTOIMMUNE-DISEASES; VENOUS INOCULATION; INDUCTION; TOLERANCE; DONOR; REQUIREMENT; GRAFTS; MICE;
Keywords:
bone marrow transplantation; hemopoietic stem cells; bone marrow stromal cells; portal vein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ikehara, S Kansai Med Univ, Dept Pathol 1, 10-15 Fumizono Cho, Moriguchi, Osaka 5708506, Japan Kansai Med Univ 10-15 Fumizono Cho Moriguchi Osaka Japan 5708506
Citazione:
T.X. Fan et al., "Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: Stromal cells as BMT-Facilitating cells", STEM CELLS, 19(2), 2001, pp. 144-150

Abstract

We examined the importance of the coadministration of bone marrow (BM) stromal cells with BM cells via the portal vein. A significant increase in thenumber of day-14 colony-forming unit-spleen (CFU-S) was observed in the recipient mice injected with hemopoietic stem cells (HSCs) along with donor BM stromal cells obtained after three to four weeks of culture. Histologicalexamination revealed that hematopoietic colonies composed of both donor hemopoietic cells and stromal cells coexist in the liver of these mice. However, when donor HSCs plus BM stromal cells were administered i.v., neither the stimulatory effects on CFU-S formation nor the hemopoietic colonies in the recipient liver were observed. These findings suggest that the interaction of HSCs with stromal cells in the liver is the first crucial step for successful engraftment of allogeneic HSCs. It is likely that donor stromal cells and HSCs trapped in the livermigrate into the recipient BM and spleen, where they form CFU-BM and CFU-S, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:36:51