Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increase in bilirubin levels of patients with obstructive sleep apnea in the morning - A possible explanation of induced heme oxygenase-1
Autore:
Chin, K; Ohi, M; Shimizu, K; Nakamura, T; Miyaoka, F; Mishima, M; Nakamura, T;
Indirizzi:
Kyoto Univ Hosp Med, Dept Phys Therapeut, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Hosp Med Kyoto Japan 6068507 , Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Resp Med, Kyoto, Japan Kyoto Univ Kyoto Japan Univ, Grad Sch Med, Dept Resp Med, Kyoto, Japan Osaka Kaisei Hosp, Osaka, Japan Osaka Kaisei Hosp Osaka JapanOsaka Kaisei Hosp, Osaka, Japan
Titolo Testata:
SLEEP
fascicolo: 2, volume: 24, anno: 2001,
pagine: 218 - 223
SICI:
0161-8105(20010315)24:2<218:IIBLOP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSION; ANTIOXIDANT; INFARCTION; EXPRESSION; MORTALITY; PRESSURE; STRESS;
Keywords:
heme oxygenase-1 (HO-1); bilirubin; nCPAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chin, K Kyoto Univ Hosp Med, Dept Phys Therapeut, Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ Hosp Med 54 Shogoin Kawahara ChoKyoto Japan 6068507 n
Citazione:
K. Chin et al., "Increase in bilirubin levels of patients with obstructive sleep apnea in the morning - A possible explanation of induced heme oxygenase-1", SLEEP, 24(2), 2001, pp. 218-223

Abstract

Study Objectives: In the absence of heme oxygenase-1 (HO-1), which catalyzes the oxidation of heme to generate carbon monoxide and indirect bilirubin, hypoxia induces severe right ventricular dilation and infarction. Despitesevere hypoxemia during sleep, patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) rarely die during sleep. We hypothesized that apnea-related hypoxemia would induce HO-1 and increase bilirubin levels in the morning in OSAHS patients. Therefore, bilirubin levels in OSAHS patients were analyzed before and after nasal continuous positive airway pressure (nCPAP) therapy. Design: Bilirubin levels in the afternoon before sleep and in the morning immediately after sleep were determined before and after nCPAP treatment. Setting: University Hospital in Kyoto, Japan. Patients: The subjects were 22 patients with OSAHS (mean (SEM) apnea and hypopnea index of 60 (5)) who were treated with nCPAP and 13 controls. Interventions: N/AMeasurements and Results: Before nCPAP treatment, total after-sleep bilirubin level was significantly higher than the pre-sleep level (p<0.0001). Thedifference between the serum indirect bilirubin levels in the morning versus in the previous afternoon [D-(M-A)-IB] decreased significantly with nCPAP treatment (p<0.01). The magnitude of decrease in D-(M-A)-IB after nCPAP treatment correlated significantly with changes in the percent time spent with arterial O-2 saturation below 90% (r=0.44; p=0.04) and 85% (r=0.49; p=0.02), respectively, during sleep after nCPAP treatment. Conclusions: The increase in bilirubin level by HO-1 might protect OSAHS patients from disorders related to hypoxemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:08:12