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Titolo:
Glycodelin: A pane in the implantation window
Autore:
Mueller, MD; Vigne, JL; Vaisse, C; Taylor, RN;
Indirizzi:
Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sch Med, Dept Med, Metab Res Unit, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
SEMINARS IN REPRODUCTIVE MEDICINE
fascicolo: 3, volume: 18, anno: 2000,
pagine: 289 - 298
SICI:
1526-8004(2000)18:3<289:GAPITI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PLACENTAL PROTEIN-14; HUMAN ENDOMETRIAL CELLS; IN-VITRO FERTILIZATION; AMINO-ACID SEQUENCE; BETA-LACTOGLOBULINS; SECRETORY PROTEINS; EPITHELIAL-CELLS; MENSTRUAL-CYCLE; GENE-EXPRESSION; EMBRYO-TRANSFER;
Keywords:
glycodelin; placental protein 14; gene expression; progestins; relaxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, RN Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & ReprodSci, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San FranciscoSan Francisco CA USA 94143 94143 USA
Citazione:
M.D. Mueller et al., "Glycodelin: A pane in the implantation window", SEMIN REP M, 18(3), 2000, pp. 289-298

Abstract

Glycodelin is an endometrial protein with proposed immunomodulatory activity during human embryonic nidation. In this review we describe the effects of ovarian hormones on glycodelin transcription, synthesis, and secretion by human epithelial cells and focus on the importance of glycodelin in implantation. We demonstrate that glycodelin transcription, synthesis, and secretion by human epithelial cells are stimulated by progestins and antiprogestins but not by estrogen. Sequences localized within a 403-base-pair region-flanking the 5' human glycodelin gene promoter appear to be responsible fortranscriptional activation of this gene mediated by progesterone receptor-ligand complexes. Relaxin, purported to enhance glycodelin production in vivo and in prior in vitro studies, had no stimulatory effect on the expression of this gene in vitro in our models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:22:23