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Titolo:
Genetic epidemiology and schizophrenia: A study of reproductive fitness
Autore:
Avila, M; Thaker, G; Adami, H;
Indirizzi:
Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr Baltimore MD USA 21228 Baltimore, MD 21228 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 47, anno: 2001,
pagine: 233 - 241
SICI:
0920-9964(20010301)47:2-3<233:GEASAS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; RURAL IRELAND; FERTILITY; RATES; BIRTH; ONSET; RISK;
Keywords:
balanced polymorphism; evolution; genetic epidemiology; reproductive fitness; (schizophrenia); siblings;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Avila, M Maryland Psychiat Res Ctr, POB 21247, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr POB 21247 Baltimore MD USA 21228 28 USA
Citazione:
M. Avila et al., "Genetic epidemiology and schizophrenia: A study of reproductive fitness", SCHIZOPHR R, 47(2-3), 2001, pp. 233-241

Abstract

Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological 'fit'. Where differential survival or reproductive success exists, genotype frequencies are altered in subsequent generations. In the case of schizophrenia, lower rates of reproduction constitute a negative selection factorthat should reduce genes in the population associated with the expression of the disease - ultimately leading to decreases in prevalence. However, studies reveal a stable prevalence of about 1% over time. Attempts to explainthe apparent contradiction between negative selection and stable prevalence have taken several forms. One explanation suggests that reproductive rates in relatives of schizophrenic patients are increased - compensating for reproductive loss in affected family members. Family data from schizophrenicpatients at the Maryland Psychiatric Research Center were compared with those of healthy volunteers and volunteers with schizophrenia spectrum personality (SSP) disorders. Controlling for important socio-cultural and demographic variables, a multiple regression model revealed a significant increasein the number of siblings associated with schizophrenia. No differences inreproductive fitness were found among normal and SSP volunteers. This observed pattern in reproductive fitness provides one mechanism by which prevalence rates can remain stable despite lower reproductive rates among individuals with schizophrenia. Evidence of increased reproductive fitness in relatives suggests the need to consider the complex interactions of proximate and ultimate (evolutionary) mechanisms in the expression of schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/12/20 alle ore 01:39:37