Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Duration of untreated psychosis predicts treatment outcome in an early psychosis program
Autore:
Black, K; Peters, L; Rui, Q; Milliken, H; Whitehorn, D; Kopala, LC;
Indirizzi:
Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada Dalhousie Univ HalifaxNS Canada niv, Dept Psychiat, Halifax, NS, Canada QEII Hlth Sci Ctr, Mental Hlth Serv, Halifax, NS, Canada QEII Hlth Sci Ctr Halifax NS Canada ental Hlth Serv, Halifax, NS, Canada Nova Scotia Hosp, Nova Scotia Early Psychosis Program, Dartmouth, NS, Canada Nova Scotia Hosp Dartmouth NS Canada osis Program, Dartmouth, NS, Canada
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 47, anno: 2001,
pagine: 215 - 222
SICI:
0920-9964(20010301)47:2-3<215:DOUPPT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; EARLY INTERVENTION; 1ST-EPISODE SCHIZOPHRENIA; ONSET; MEDICATION; ILLNESS; IMPACT;
Keywords:
early psychosis program; treatment outcome; untreated psychosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Whitehorn, D Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada Dalhousie Univ Halifax NS Canada chiat, Halifax, NS, Canada
Citazione:
K. Black et al., "Duration of untreated psychosis predicts treatment outcome in an early psychosis program", SCHIZOPHR R, 47(2-3), 2001, pp. 215-222

Abstract

For patients first presenting with a non-affective psychotic disorder, theduration of untreated psychosis (DUP; the time between the onset of positive psychotic symptoms and the initiation of appropriate treatment) varies widely, from a few weeks to several years. A number of studies report that alonger DUP is associated with poorer clinical outcomes. We studied DUP andits association with clinical outcomes in a group of patients with schizophrenia and related psychotic disorders treated in the naturalistic clinicalsetting of an early psychosis program. DUP was determined for 19 patients with a non-affective psychotic disorder (schizophrenia, schizoaffective disorder or schizophreniform disorder) and no previous treatment for psychosis, by use of the IRAOS, a retrospective structured interview carried out with patients and their families. Positive and Negative Syndrome Scale (PANSS)and Global Assessment of Function (GAF) ratings were available at baselineand 6 month follow-up. For analysis, patients were categorized into a short DUP (n = 9) or long DUP (n = 10) group. The median DUP (57 weeks) was used as the dividing point. At baseline, the two groups did not differ significantly on positive symptoms or total PANSS ratings. However, negative symptoms were more severe in the long DUP group at baseline (P = 0.029), and thelong DUP group had a significantly higher mean rating for the passive/apathetic social withdrawal item of the PANSS (P = 0.024). At 6 month followup,the long DUP group had significantly higher ratings for positive symptoms (P = 0.028) and had lower GAF scores (P = 0.044). Significantly more (P = 0.033) long DUP patients had enduring positive psychotic symptoms. The results confirm both the wide range of DUP among patients first presenting with schizophrenia and related psychotic disorders and the association of long DUP, defined as greater than approximately 1 year, with a poorer clinical outcome. This study highlights the importance of collecting data regarding DUP and supports the view that patients with a long DUP are likely to be lessresponsive to treatment in general and will require greater resources and more intensive interventions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:53:15