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Titolo:
Pulmonary involvement in juvenile dermatomyositis: a two-year longitudinalstudy
Autore:
Trapani, S; Camiciottoli, G; Vierucci, A; Pistolesi, M; Falcini, F;
Indirizzi:
Univ Florence, Dept Paediat, Rheumatol Unit, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 matol Unit, I-50121 Florence, Italy Univ Florence, Dept Crit Care, Resp Unit, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 Resp Unit, I-50121 Florence, Italy
Titolo Testata:
RHEUMATOLOGY
fascicolo: 2, volume: 40, anno: 2001,
pagine: 216 - 220
SICI:
1462-0324(200102)40:2<216:PIIJDA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDREN AGED 4; LUNG-FUNCTION; POLYMYOSITIS-DERMATOMYOSITIS; DISEASE; AUTOANTIBODIES; CHILDHOOD; MUSCLE;
Keywords:
juvenile dermatomyositis; pulmonary function tests;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Trapani, S A Meyer Hosp, Dept Paediat, Rheumatol Unit, Via Luca Giordano 13, I-50132 Florence, Italy A Meyer Hosp Via Luca Giordano 13 Florence Italy I-50132 Italy
Citazione:
S. Trapani et al., "Pulmonary involvement in juvenile dermatomyositis: a two-year longitudinalstudy", RHEUMATOLOG, 40(2), 2001, pp. 216-220

Abstract

Objective. To investigate the prevalence and features of asymptomatic pulmonary involvement in juvenile dermatomyositis (JDM). Methods. Twelve JDM patients underwent pulmonary function tests at baseline, 12 and 24 months. Disease activity, duration, serum lactate dehydrogenase (LDH) values and antinuclear antibody (ANA) titres were also evaluated. Results. Five patients showed lung impairment at baseline and four at 12 and 24 months. Forced expiratory volume in 1 s, forced vital capacity (FVC),carbon monoxide diffusing capacity (DLCO) and alveolar volume were the most frequently altered variables, indicating a restrictive pattern and impairment of diffusion. The prevalence and features of pulmonary alterations didnot change during follow-up. FVC values were significantly lower in activeJDM patients and were inversely related to LDH. DLCO values were significantly lower in ANA-positive patients. About half of the patients of this small case series of JDM had asymptomatic lung disease. Conclusions. We suggest that lung function should be evaluated at disease onset and regularly during follow-up, as pulmonary function tests can detect otherwise unpredictable pulmonary involvement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:48:53