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Titolo:
Human parvovirus B19 infection in patients with systemic lupus erythematosus
Autore:
Hsu, TC; Tsay, GJ;
Indirizzi:
Chung Shan Med & Dent Coll, Dept Med, Taichung 402, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 402 Med, Taichung 402, Taiwan Chung Shan Med & Dent Coll, Inst Immunol, Taichung 402, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 402 nol, Taichung 402, Taiwan Chung Shan Med & Dent Coll, Inst Med, Taichung 402, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 402 Med, Taichung 402, Taiwan
Titolo Testata:
RHEUMATOLOGY
fascicolo: 2, volume: 40, anno: 2001,
pagine: 152 - 157
SICI:
1462-0324(200102)40:2<152:HPBIIP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; UNIQUE REGION; B19-PARVOVIRUS; MANIFESTATIONS; CLASSIFICATION; DIAGNOSIS; CRITERIA; SURFACE; DISEASE; PROTEIN;
Keywords:
human parvovirus b19; systemic lupus erythematosus; nested PCR; hypocomplementaemia; Raynaud's phenomenon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tsay, GJ Chung Shan Med & Dent Coll, Dept Med, 110 Sec 1,Chien Kuo N Rd, Taichung 402, Taiwan Chung Shan Med & Dent Coll 110 Sec 1,Chien Kuo N Rd Taichung Taiwan 402
Citazione:
T.C. Hsu e G.J. Tsay, "Human parvovirus B19 infection in patients with systemic lupus erythematosus", RHEUMATOLOG, 40(2), 2001, pp. 152-157

Abstract

Objective. The clinical significance of the presence of B19 DNA in patients with SLE was studied. Methods. Sera from 72 patients with systemic lupus erythematosus (SLE), 23patients with rheumatoid arthritis (RA), 18 patients with Sjogren's syndrome (SS), eight patients with Raynaud's phenomenon (RP), five patients with primary biliary cirrhosis (PBC), five patients with polymyositis (PM), fourpatients with erythema infectiosum (EI) and 22 normal controls were examined for parvovirus B19 (B19) infection by serological assays, nested PCR andSouthern blotting. Results. Parvovirus B19 DNA was detected in 17 of 72 patients with SLE andin three of four patients with EI, but not in patients with other systemicrheumatic diseases. Of the 17 patients with B19 DNA, only one had IgG anti-B19 antibody and two had IgM anti-B19 antibodies, whereas IgG and IgM anti-B19 antibodies were detected in 27 (49.1%) and 21 (38.2%) of 55 SLE patients without B19 DNA respectively. All sera from the patients with ET contained both IgG and IgM anti-B19 antibodies. B19 DNA was found more commonly insera from LE patients without anti-B19 antibodies than in those with anti-B19 antibodies (P < 0.05). Conclusions. B19 infection in patients with SLE may be due to lack of anti-B19 antibodies because of either the immunocompromised nature of the host or the use of immunosuppressive drugs. There was a higher prevalence of hypocomplementaemia and RP in patients with parvovirus B19 viraemia than in those without parvovirus B19 viraemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:25:40