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Titolo:
Insulin status and adjustment in type 2 diabetic patients' treatment.
Autore:
Bosquet, F; Heurtier, A; Chastang, N; Jacqueminet, S;
Indirizzi:
CHU, Hop La Pitie Salpetriere, Serv Diabetol Metabolisme, F-75651 Paris 13, France CHU Paris France 13 Serv Diabetol Metabolisme, F-75651 Paris 13, France
Titolo Testata:
REVUE DE MEDECINE INTERNE
fascicolo: 3, volume: 22, anno: 2001,
pagine: 265 - 273
SICI:
0248-8663(200103)22:3<265:ISAAIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
FRE
Soggetto:
SECONDARY SULFONYLUREA FAILURE; GLYCEMIC CONTROL; POSTPRANDIAL HYPERGLYCEMIA; RANDOMIZED TRIAL; TREATED PATIENTS; BEDTIME INSULIN; CLINICAL-TRIAL; WEIGHT-GAIN; THERAPY; MELLITUS;
Keywords:
type 2 diabetes; insulin therapy; oral hypoglycemic drugs; combined therapy; bedtime NPH insulin; weight gain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Bosquet, F CHU, Hop La Pitie Salpetriere, Serv Diabetol Metabolisme, 47-83Blvd Hop, F-75651 Paris 13, France CHU 47-83 Blvd Hop Paris France 13 p, F-75651 Paris 13, France
Citazione:
F. Bosquet et al., "Insulin status and adjustment in type 2 diabetic patients' treatment.", REV MED IN, 22(3), 2001, pp. 265-273

Abstract

Introduction. -The natural history of type 2 diabetes mellitus is characterized by an inescapable and gradual worsening of a decrease in insulin secrection. Thus after several years of progress, less than half of type 2 diabetic patients have good glycemic control. This explains the increase in insulin prescription to type 2 diabetic patients in France in recent years. This work's objective is to take into account recent publication data to clarify the status of and adjustments in insulin therapy. Current knowledge and key points. -The benefit of insulin treatment-mediated glycemic control optimization on microvascular complications is now proven. However, there is still controversy concerning macrovascular complications. Hypoglycemic risk in type 2 diabetic patients is limited and the main problem with insulin treatment is weight gain. Following failure with treatment by tablets, the most suitable treatment in terms of metabolic improvement, weight gain limitation and treatment adhesion is to add an intermediate insulin injection at bedtime. The next step remains several injections a day, with metformine addition if possible. Future prospects and projects. -Therapeutic treatment in type 2 diabetes mellitus may become an earlier start of insulin therapy to preserve the remaining pancreatic insulin reserve. The role of brief and long-lasting insulin analogues, as well as inhaled insulin, which will soon be available, should be specified. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:41