Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy
Autore:
Pritchard, J; Anand, P; Broome, J; Davis, C; Gothard, L; Hall, E; Maher, J; McKinna, F; Millington, J; Misra, VP; Pitkin, A; Yarnold, JR;
Indirizzi:
Royal Marsden Hosp, Acad Radiotherapy Unit, Sutton SM2 5PT, Surrey, England Royal Marsden Hosp Sutton Surrey England SM2 5PT SM2 5PT, Surrey, England Radiotherapy Act Grp Exposure, Bromley BR1 2UA, Kent, England RadiotherapyAct Grp Exposure Bromley Kent England BR1 2UA Kent, England Hammersmith Hosp, Imperial Coll Sch Med, London W12 0NN, England Hammersmith Hosp London England W12 0NN Sch Med, London W12 0NN, England Biggen House Farm, Esh DH7 9RP, Durham, England Biggen House Farm Esh Durham England DH7 9RP Esh DH7 9RP, Durham, England Moorgreen Hosp, Southampton SO30 3JB, Hants, England Moorgreen Hosp Southampton Hants England SO30 3JB O30 3JB, Hants, England Inst Canc Res, Clin Trials & Stat Unit, Sutton SM2 5NG, England Inst Canc Res Sutton England SM2 5NG Stat Unit, Sutton SM2 5NG, England Mt Vernon Hosp, Dept Clin Oncol, Northwood HA6 2RN, England Mt Vernon Hosp Northwood England HA6 2RN col, Northwood HA6 2RN, England Maimonides Hosp, Dept Clin Oncol, Maidstone ME16 9QQ, Kent, England Maimonides Hosp Maidstone Kent England ME16 9QQ e ME16 9QQ, Kent, England St Marys Hosp, Dept Clin Neurophysiol, London W2 1NY, England St Marys Hosp London England W2 1NY Neurophysiol, London W2 1NY, England Inst Naval Med, Gosport PO12 2DL, England Inst Naval Med Gosport EnglandPO12 2DL l Med, Gosport PO12 2DL, England
Titolo Testata:
RADIOTHERAPY AND ONCOLOGY
fascicolo: 3, volume: 58, anno: 2001,
pagine: 279 - 286
SICI:
0167-8140(200103)58:3<279:DRPISO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEMORRHAGIC CYSTITIS; INDUCED OPTIC NEUROPATHY; THERAPY; OSTEORADIONECROSIS; ANGIOGENESIS; IRRADIATION; NECROSIS; CANCER; TISSUE;
Keywords:
hyperbaric oxygen therapy; clinical trials; radiotherapy complications; brachial plexopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yarnold, JR Royal Marsden Hosp, Acad Radiotherapy Unit, Downs Rd, Sutton SM2 5PT, Surrey, England Royal Marsden Hosp Downs Rd Sutton Surrey England SM2 5PT land
Citazione:
J. Pritchard et al., "Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy", RADIOTH ONC, 58(3), 2001, pp. 279-286

Abstract

Background: Radiation-induced brachial plexopathy (RIBP) is an untreatablecomplication of curative radiotherapy for early breast cancer, characterized by chronic neuropathic pain and limb paralysis. Hyperbaric oxygen (HBO2)therapy is known to promote healing of tissue rendered ischaemic by radiotherapy, but is untested in RIBP. Methods: Thirty four eligible research volunteers suffering from RIBP wererandomized to HBO2 or control group. The HBO2 group breathed 100% oxygen for 100 min in a multiplace hyperbaric chamber on 30 occasions over a periodof 6 weeks. The control group accompanied the HBO2 group and breathed a gas mixture equivalent to breathing 100% oxygen at surface pressure. All volunteers and investigators, except the operators of the hyperbaric chamber and the trial statistician, were blind to treatment assignments. The warm sensory threshold, which measures the function of small sensory fibres, was selected as the primary endpoint. Findings: Pre-treatment neurophysiological tests were grossly abnormal in the affected hand compared to the unaffected hand in both HBO2 and control groups, as expected, but no statistically significant differences were noted in either group at any time up to 12 months posttreatment. However, normalization of the warm sensory threshold in two of the HBO2 group was reliably recorded. Two cases with marked chronic arm lymphoedema reported major and persistent improvements in arm volume for at least 12 months after treatment with HBO2. Interpretation: There is no reliable evidence to support the hypothesis that HBO2 therapy slows or reverses RIBP in a substantial proportion of affected individuals, although improvements in warm sensory threshold offer somesuggestion of therapeutic effect. Improvement in long-standing arm lymphoedema was not anticipated, and justifies further investigation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:37:05