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Titolo:
Temporal lobe epilepsy: Qualitative reading of H-1 MR spectroscopic imagesfor presurgical evaluation
Autore:
Capizzano, AA; Vermathen, P; Laxer, KD; Ende, GR; Norman, D; Rowley, H; Matson, GB; Maudsley, AA; Segal, MR; Weiner, MW;
Indirizzi:
Dept Vet Affairs Med Ctr, Magnet Resonance Spect Unit 114M, San Francisco,CA 94121 USA Dept Vet Affairs Med Ctr San Francisco CA USA 94121 rancisco,CA 94121 USA Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Div Biostat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 218, anno: 2001,
pagine: 144 - 151
SICI:
0033-8419(200101)218:1<144:TLEQRO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; HIPPOCAMPAL SCLEROSIS; LATERALIZATION; LOBECTOMY; SEIZURES; SURGERY;
Keywords:
brain, MR; epilepsy; magnetic resonance (MR), comparative studies; magnetic resonance (MR), spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, MW Dept Vet Affairs Med Ctr, Magnet Resonance Spect Unit 114M, 4150 Clement St, San Francisco, CA 94121 USA Dept Vet Affairs Med Ctr 4150 Clement St San Francisco CA USA 94121
Citazione:
A.A. Capizzano et al., "Temporal lobe epilepsy: Qualitative reading of H-1 MR spectroscopic imagesfor presurgical evaluation", RADIOLOGY, 218(1), 2001, pp. 144-151

Abstract

PURPOSE: To study the feasibility and clinical potential of visual inspection of hydrogen 1 magnetic resonance (MR) spectroscopic metabolite images for the lateralization of Unilateral nonlesional temporal lobe epilepsy (TLE). MATERIALS AND METHODS: MR imaging and H-1 MR spectroscopic imaging were performed of the temporal lobes in 50 patients with TLE and 23 age-matched healthy volunteers. N-acetylaspartate (NAA) and creatine plus choline metabolite images were read by two neuroradiologists who determined lateralizationaccording to the side of lower NAA signal intensity. Quantitative estimates of NAA were calculated by using an automated fitting program. RESULTS:Agreement in lateralization between readers was significant with akappa score of 0.53 for all patients with TLE and 0.63 for patients displaying mild or marked NAA asymmetry. Among the 50 patients with TLE, lateralization was determined correctly by reader 1 in 38 (76%) patients and by reader 2 in 31 (62%) patients. If limited to patients with mild or marked NAA asymmetry, correct lateralization improved to 30 (77%) of 39 and 16 (80%) of 20 patients, respectively. Combined qualitative reading and quantitative spectral fitting enabled lateralization in 34 (85%) of 40 patients with TLEfor reader 1 and 30 (77%) of 39 for reader 2, including nine of 14 patients with TLE with negative MR images. CONCLUSION: Reading of metabolite images is a feasible and fast means for noninvasive evaluation of patients with TLE who are candidates for surgery and enables lateralization in some patients with negative MR images.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:33:56