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Titolo:
The differential effects of prenatal stress in rats on the acoustic startle reflex under baseline conditions and in response to anxiogenic drugs
Autore:
White, DA; Birkle, DL;
Indirizzi:
W Virginia Univ, Dept Pharmacol & Toxicol, Sch Med, Robert C Byrd Hlth SciCtr, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 SciCtr, Morgantown, WV 26506 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 154, anno: 2001,
pagine: 169 - 176
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; FEAR-POTENTIATED STARTLE; PREPULSE INHIBITION; MATERNAL STRESS; ADULT-RATS; RECEPTOR AGONISTS; INDUCED BEHAVIOR; FACTOR CRF; YOHIMBINE; BRAIN;
Keywords:
prenatal stress; acoustic startle; alpha(2)-adrenergic antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Birkle, DL W Virginia Univ, Dept Pharmacol & Toxicol, Sch Med, Robert C Byrd Hlth SciCtr, POB 9223, Morgantown, WV 26506 USA W Virginia Univ POB 9223Morgantown WV USA 26506 , WV 26506 USA
Citazione:
D.A. White e D.L. Birkle, "The differential effects of prenatal stress in rats on the acoustic startle reflex under baseline conditions and in response to anxiogenic drugs", PSYCHOPHAR, 154(2), 2001, pp. 169-176

Abstract

Rationale: The prenatal stress syndrome (PS) is characterized by exaggerated behavioral and physiological responses to stressful stimuli and anxiogenic agents. Objectives: To characterize the behavioral effects of PS on the acoustic startle reflex (ASR) and to determine the possible role of PS-induced alterations in noradrenergic control of ASR by determining the effects of the alpha (2)-adrenoceptor antagonists, yohimbine, idazoxan, and RS79948-197. Methods: PS was induced by exposing pregnant dams to a mild stressor of handling and saline injection (0.1 ml, s.c.) from gestational days 14 to21. Control darns were left undisturbed throughout pregnancy. Using adult male offspring, all ASR studies consisted of either a 30- or 60 min testingperiod containing 60 or 120 acoustic startle stimuli trials (95 dB, 50 ms noise burst) at a fixed intertrial interval of 30 s after a 5-min acclimation period. For drug studies, a 3-day repeated measures design was implemented. Results: With the exception of the response to the first startle stimulus on the first day of testing, there were no significant differences in baseline ASR between control and PS offspring. Low doses of yohimbine, idazoxan, and RS79948-197 were anxiogenic in the ASR test in both control and PS offspring. PS offspring were less responsive to higher doses of yohimbine (5 mg/kg) and idazoxan (8 mg/kg) but did not differ from control in their responses to any dose of RS79948-197. Conclusions: Anxiogenic effects of yohimbine, idazoxan, and RS79978-197, likely mediated via alpha (2)-adrenoceptor blockade, are similar in control and PS rats. Differences between controland PS rats occurred in the response to higher doses of yohimbine and idazoxan. Non-specific effects of these drugs, such as actions at 5HT(1A) receptors, may cause their behavioral profile to be altered by PS, and to differfrom the highly selective RS79948-197.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:48:03