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Titolo:
Gender differences in the subjective effects of MDMA
Autore:
Liechti, ME; Gamma, A; Vollenweider, FX;
Indirizzi:
Univ Hosp Psychiat Zurich, CH-8029 Zurich, Switzerland Univ Hosp Psychiat Zurich Zurich Switzerland CH-8029 Zurich, Switzerland
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 154, anno: 2001,
pagine: 161 - 168
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPTAKE INHIBITOR CITALOPRAM; HEALTHY-VOLUNTEERS; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONIN NEUROTOXICITY; RECREATIONAL USERS; ECSTASY MDMA; HUMANS; MECHANISM; NEUROENDOCRINE; RELEASE;
Keywords:
3,4-methylenedioxymethamphetamine; MDMA; ecstasy; gender; human; psychological effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Liechti, ME Univ Hosp Psychiat Zurich, POB 68, CH-8029 Zurich, SwitzerlandUniv Hosp Psychiat Zurich POB 68 Zurich Switzerland CH-8029 d
Citazione:
M.E. Liechti et al., "Gender differences in the subjective effects of MDMA", PSYCHOPHAR, 154(2), 2001, pp. 161-168

Abstract

Rationale: 3,4-Methylenedioxymethamphetamine (MDMA) mainly releases serotonin (5-HT) and is contained in the recreational drug Ecstasy. 5-HT is knownto play an important role in mood and anxiety disorders, for which there is a female preponderance. To date, there are no systematic data on gender differences in the subjective effects of MDMA. Objectives: The present work analyzed the pooled data from three controlled studies on the psychologicaland physiological effects of MDMA in healthy volunteers with no or minimalMDMA experience. A particular focus of the analyses were possible gender differences. Methods: A total of 74 subjects (54 male, 20 female) participated in all three studies. MDMA in oral, doses ranging from 70-150 mg (1.35-1.8 mg/kg) was administered under double-blind placebo-controlled conditions. Subjective peak changes were assessed by standardized psychometric ratingscales. Physiological measures were blood pressure, heart rate, and peripheral body temperature. Adverse drug effects were assessed during the experimental session and after 24 h, Results: Psychoactive effects of MDMA were more intense in women than in men. Women especially had higher scores for MDMA-induced perceptual changes, thought disturbances, and fear of loss of body control. The dose of MDMA positively correlated with the intensity of perceptual changes in women. Acute adverse effects and sequelae were also more frequent in female than in male subjects. In contrast, men showed higher increases in blood pressure than woman. Conclusions: The fact that equal doses of MDMA per kilogram body weight produce stronger responses in women compared to men is consistent with an increased susceptibility of women to the 5-HT-releasing effects of MDMA. Our results also indicate that increasingdoses of MDMA produce more hallucinogen-like perceptual alterations, particularly in women.

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Documento generato il 22/01/20 alle ore 06:27:36