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Titolo:
Syndromes of schizophrenia and smooth-pursuit eye movement dysfunction
Autore:
Lee, KH; Williams, LM; Loughland, CM; Davidson, DJ; Gordon, E;
Indirizzi:
Univ Sydney, Westmead Hosp, Brain Dynam Ctr, Cognit Neurosci Unit, Sydney,NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ci Unit, Sydney,NSW 2006, Australia Univ Sydney, Dept Psychol, Sydney, NSW 2006, Australia Univ Sydney SydneyNSW Australia 2006 sychol, Sydney, NSW 2006, Australia Univ New England, Sch Psychol, Armidale, NSW 2351, Australia Univ New England Armidale NSW Australia 2351 rmidale, NSW 2351, Australia Univ Sydney, Dept Psychol Med, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ol Med, Sydney, NSW 2006, Australia
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 1, volume: 101, anno: 2001,
pagine: 11 - 21
SICI:
0165-1781(20010214)101:1<11:SOSASE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACKING DYSFUNCTION; NEGATIVE SYMPTOMS; CORTICAL CONTROL; PERFORMANCE; DISORDER; ABNORMALITIES; RELATIVES; BRAIN; DEFICITS; LESIONS;
Keywords:
schizophrenia; syndromes; smooth pursuit eye movement (SPEM); factor analysis; disorganization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KH Univ Sydney, Westmead Hosp, Brain Dynam Ctr, Cognit Neurosci Unit,Sydney,NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 Sydney,NSW 2006, Australia
Citazione:
K.H. Lee et al., "Syndromes of schizophrenia and smooth-pursuit eye movement dysfunction", PSYCHIAT R, 101(1), 2001, pp. 11-21

Abstract

There have been a number of studies on smooth pursuit eye movement (SPEM) dysfunction in schizophrenia. However, the association between SPEM dysfunction and particular clinical symptoms remains unclear. We examined SPEM dysfunction in relation to schizophrenic symptoms using both the positive/negative dichotomy and the three-syndrome model. Subjects included 78 patients with schizophrenia and 60 healthy control subjects. SPEM performance was indexed by root mean square error. Symptom profiles were assessed using the Positive and Negative Syndrome Scale (PANSS), and the three-primary syndromes were identified by factor analysis of PANSS ratings (Psychomotor poverty:deficit negative symptoms; Disorganization: defined primarily by thought disorder; and Reality distortion: hallucinations and delusions). Compared with controls, the schizophrenia group showed significant impairment in global SPEM function. The three-syndrome approach produced more specific findings than the dichotomous model. Of the three syndromes, only the Disorganization dimension showed a significant association with increased global SPEM dysfunction. The specificity of SPEM dysfunction to Disorganization was verified in comparisons among schizophrenia subgroups and the control group. Bycontrast, the general domains of positive and negative symptoms were both found to be modestly associated with SPEM dysfunction. The separation of positive and negative symptoms that contribute to Disorganization from those that define Reality Distortion and Psychomotor Poverty has revealed significant new associations between SPEM and schizophrenic symptoms. These findings are interpreted in light of the proposal that the Disorganization syndrome is the central form of pathology in schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 27/01/20 alle ore 08:14:48