Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transcriptional activity of the TFIIA four-helix bundle in vivo
Autore:
Stargell, LA; Ogg, RC; Adkins, JN; Robinson, MM; Lumb, KJ;
Indirizzi:
Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 hem, Ft Collins, CO 80523 USA
Titolo Testata:
PROTEINS-STRUCTURE FUNCTION AND GENETICS
fascicolo: 2, volume: 43, anno: 2001,
pagine: 227 - 232
SICI:
0887-3585(20010501)43:2<227:TAOTTF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TATA-BINDING PROTEIN; YEAST TFIIA/TBP/DNA COMPLEX; II GENE-TRANSCRIPTION; RNA-POLYMERASE-II; ACTIVATION DOMAIN; ARTIFICIAL RECRUITMENT; CIRCULAR-DICHROISM; CRYSTAL-STRUCTURE; IN-VIVO; PROMOTER;
Keywords:
transcription; TFIIA; four-helix bundle; yeast; protein structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Stargell, LA Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 ns, CO 80523 USA
Citazione:
L.A. Stargell et al., "Transcriptional activity of the TFIIA four-helix bundle in vivo", PROTEINS, 43(2), 2001, pp. 227-232

Abstract

TFIIA contributes to transcription initiation by stabilizing the TBP-TATA interaction and by mediating the response to transcriptional activators andinhibitors. TFIIA contains a six-stranded P-sheet domain and a four-helix bundle. The p-domain makes functional contacts with DNA and TBP, The role of the four-helix bundle was investigated using a structure-based model of this domain (called 4HB), 4HB adopts a highly stable, helical fold, consistent with its structure in the context of TFIIA, Like TBP and other intact transcription factors, 4HB is able to activate transcription in vivo when artificially recruited to a promoter via a heterologous DNA-binding domain. Thus, in addition to making important contacts with TBP and DNA via the p-domain, TFIIA makes other specific, functional contacts with the transcriptional machinery via the four-helix bundle. (C) 2001 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:24:48