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Titolo:
EFFECTS OF MILNACIPRAN AND PINDOLOL ON EXTRACELLULAR NORADRENALINE AND SEROTONIN LEVELS IN GUINEA-PIG HYPOTHALAMUS
Autore:
MORET C; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81100 CASTRES FRANCE
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 69, anno: 1997,
pagine: 815 - 822
SICI:
0022-3042(1997)69:2<815:EOMAPO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; 5-HT AUTORECEPTORS; INVIVO MICRODIALYSIS; DORSAL RAPHE; IN-VIVO; RELEASE; RECEPTORS; DEPRESSION; CITALOPRAM; ANTAGONIST;
Keywords:
MILNACIPRAN; NORADRENALINE; SEROTONIN; REUPTAKE; ANTIDEPRESSANT; 5-HYDROXYTRYPTAMINE(1A) ANTAGONIST; (-)-PINDOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
C. Moret e M. Briley, "EFFECTS OF MILNACIPRAN AND PINDOLOL ON EXTRACELLULAR NORADRENALINE AND SEROTONIN LEVELS IN GUINEA-PIG HYPOTHALAMUS", Journal of neurochemistry, 69(2), 1997, pp. 815-822

Abstract

Milnacipran, a dual noradrenaline (NA) and serotonin (5-hydroxytryptamine, 5-HT) uptake inhibitor, increased extracellular levels of NA and5-HT in hypothalamus of freely moving guinea pigs as measured by microdialysis. The basal levels of both monoamines, which were tetrodotoxin sensitive, were increased in a dose-dependent manner and to a similar extent after the intraperitoneal administration of milnacipran (10 and 40 mg/kg i.p.). Levels of the NA metabolite 4-hydroxy-3-methoxyphenylglycol (MHPG) were decreased by milnacipran at 10 and 40 mg/kg i.p.,whereas those of the 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) showed no effect. Subcutaneous injection of 5-HT1A and beta-adrenergic receptor antagonist (-)-pindolol alone, at 10 mg/kg, had no effect on the extracellular levels of NA or 5-HT. The concomitant administration of (-)-pindolol (10 mg/kg s.c.) with milnacipran (10 mg/kg i.p.)increased severalfold the effect of milnacipran on the extracellular levels of NA and 5-HT. These results indicate that milnacipran, by blocking the uptake of NA and 5-HT, increases virtually equipotently the extracellular levels of NA and 5-HT, confirming previous in vitro studies. In addition, the antagonism of 5-HT1A autoreceptors by (-)-pindolol potentiates the action of milnacipran on both NA and 5-HT systems, without modifying the ratio of these activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:07:49