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Titolo:
Modulation of PGE(2) generation in the diabetic embryo: effect of nitric oxide and superoxide dismutase
Autore:
Jawerbaum, A; Sinner, D; White, V; Pustovrh, C; Capobianco, E; Gimeno, MAF; Gonzalez, ET;
Indirizzi:
CONICET, CEFYBO, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos AiresDF Argentina RA-1033 033 Buenos Aires, DF, Argentina
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 2, volume: 64, anno: 2001,
pagine: 127 - 133
SICI:
0952-3278(200102)64:2<127:MOPGIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-E GENERATION; OOCYTE-CUMULUS COMPLEXES; MOUSE EMBRYOS; ARACHIDONIC-ACID; RAT; HYPERGLYCEMIA; INHIBITION; SYNTHASE; ANOMALIES; REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Jawerbaum, A Serrano 669, RA-1414 Buenos Aires, DF, Argentina Serrano 669Buenos Aires DF Argentina RA-1414 DF, Argentina
Citazione:
A. Jawerbaum et al., "Modulation of PGE(2) generation in the diabetic embryo: effect of nitric oxide and superoxide dismutase", PROS LEUK E, 64(2), 2001, pp. 127-133

Abstract

In this work we assessed NO levels in the control and diabetic embryo during early organogenesis, and the ability of NO and SOD to modify embryonic PGE(2) levels. Rats were made diabetic by steptozotocin (60 mg/kg) before mating. Diabetic embryos (day 10 of gestation) show increased nitrate/nitritelevels and enhanced NOS activity. The diabetic embryos release to the incubation medium increased amounts of PGE(2) and have diminished PGE(2) content. In the control embryo NO modulates PGE(2) levels, but this modulatory pathway is not observed in the diabetic embryos. The diminished PGE(2) content and the enhanced PGE(2) release is prevented by SOD additions, both in the diabetic embryos and in control embryos cultured in the presence of diabetic serum (24 h culture, explantation day 9). The present results show thatSOD additions prevent the abnormalities in the accumulation, production and release of PGE(2) in diabetic embryos, probably related to the decrease in malformations. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:32:40