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Titolo:
Nitric oxide and peroxynitrite as factors to stimulate neurotransmitter release in the CNS
Autore:
Ohkuma, S; Katsura, M;
Indirizzi:
Kawasaki Med Sch, Dept Pharmacol, Kurashiki, Okayama 7010192, Japan Kawasaki Med Sch Kurashiki Okayama Japan 7010192 , Okayama 7010192, Japan
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 1, volume: 64, anno: 2001,
pagine: 97 - 108
SICI:
0301-0082(200105)64:1<97:NOAPAF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL CORTICAL-NEURONS; RAT HIPPOCAMPAL SLICES; EVOKED ACETYLCHOLINE-RELEASE; HYDROXYL RADICAL SCAVENGERS; AMINOBUTYRIC-ACID RELEASE; CARRIER-MEDIATED RELEASE; CENTRAL-NERVOUS-SYSTEM; STRIATUM IN-VITRO; H-3 GABA RELEASE; DOPAMINE RELEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Ohkuma, S Kawasaki Med Sch, Dept Pharmacol, Kurashiki, Okayama 7010192, Japan Kawasaki Med Sch Kurashiki Okayama Japan 7010192 7010192, Japan
Citazione:
S. Ohkuma e M. Katsura, "Nitric oxide and peroxynitrite as factors to stimulate neurotransmitter release in the CNS", PROG NEUROB, 64(1), 2001, pp. 97-108

Abstract

This review summarizes the stimulatory potentials of NO and peroxynitrite (OONO-) on neurotransmitter release in the central nervous system. Exogenous and endogenous NO stimulates to release neurotransmitter. NO synthesized intracellularly diffuses out through neuronal membrane and acts on the outer side of membrane to depolarize neuronal membrane, which triggers neurotransmitter release. NO-induced release of neurotransmitters is mediated by Ca2+-dependent and -independent processes. The latter process is operated by reverse process of the Na+-dependent carrier-mediated neurotransmitter uptake system or by unknown mechanisms. Ca2+-dependent release of neurotransmitter occurs in part subsequent to increase in Ca2+ influx via VDCCs, although N-type VDCCs may not involve in this action of NO because of suppression of Ca2+ influx through N-type VDCCs by NO. Participation of cGMP formation by NO on neurotransmitter release is controversial. A superoxide scavenger,Cu2+, Zn2+-superoxide dismutase, abolishes NO-induced neurotransmitter release and synthesized OONO- induces neurotransmitter release, indicating that OONO- participates in NO-evoked neurotransmitter release. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:14:48