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Titolo:
[F-18]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease
Autore:
Okamura, N; Arai, H; Higuchi, M; Tashiro, M; Matsui, T; Hu, XS; Takeda, A; Itoh, M; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ed, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ol, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Ctr Cyclotron & Radioisotope, Div Nucl Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ed, Sendai, Miyagi 9808574, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 447 - 456
SICI:
0278-5846(200102)25:2<447:[SIDWL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY DISEASE; PARKINSONS-DISEASE; DIAGNOSIS; FEATURES;
Keywords:
familiar dementia with Lewy bodies; Alzheimer's disease; positron emission tomography;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, H Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ai, Miyagi 9808574, Japan
Citazione:
N. Okamura et al., "[F-18]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease", PROG NEUR-P, 25(2), 2001, pp. 447-456

Abstract

1. The authors report two siblings with dementia with Lewy bodies (DLB). Both the older brother and the younger sister underwent positron emission tomography (PET) studies with [F-18]-2-fluoro-deoxy-D-glucose (FDG) during life. The FDG-PET study demonstrated unique and pronounced metabolic impairment in the occipital cortex in both patients. The clinical diagnosis of DLB in the sister was confirmed by autopsy.2. FDG-PET images from 11 patients with Alzheimer's disease (AD), 7 patients with DLB and 10 age-matched normal subjects were obtained and analyzed by the statistical parametric mapping (SPM) method. The SPM demonstrated a widespread metabolic reduction in the DLB group. The reduction was particularly pronounced in the visual association cortex in the DLB group compared to the AD group irrespective of clinical severity of the disease.3. These findings suggest that functional neuroimaging techniques, including FDG-PET, will provide a valuable diagnostic aid to differentiate DLB from AD, and this will help detect DLB patients in the early stage of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:59:54