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Titolo:
Effect of acute lipopolysaccharide administration on (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane-induced wet dog shake behavior in rats: Comparison with body weight change and locomotor activity
Autore:
Kouhata, SI; Kagaya, A; Nakae, S; Nakata, Y; Yamawaki, S;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Dept Pharmacol, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 armacol, Hiroshima 7348551, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 2, volume: 25, anno: 2001,
pagine: 395 - 407
SICI:
0278-5846(200102)25:2<395:EOALAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; KILLER-CELL-ACTIVITY; MAJOR DEPRESSION; RECEPTOR-BINDING; CALCIUM MOBILIZATION; AFFECTIVE-DISORDERS; BLOOD-PLATELETS; GLIOMA-CELLS; SEROTONIN; STRESS;
Keywords:
body weight; indomethacin; lipopolysaccharide; locomotor activity; naltrexone; TNF-alpha; wet dog shake;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Yamawaki, S Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Minami Ku, Kasumi 1-2-3, Hiroshima 7348551, Japan Hiroshima Univ Kasumi 1-2-3 Hiroshima Japan 7348551 51, Japan
Citazione:
S.I. Kouhata et al., "Effect of acute lipopolysaccharide administration on (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane-induced wet dog shake behavior in rats: Comparison with body weight change and locomotor activity", PROG NEUR-P, 25(2), 2001, pp. 395-407

Abstract

1. Several reports have shown that serotonin (5-HT)(2A) receptor density and its function are altered after physiological or pharmacological stress. To examine whether an acute administration of lipopolysaccharide (LPS), a bacterial endotoxin, affected 5-HT2A receptor function, wet dog shakes of male Wistar rats were observed after a subcutaneous injection of DOT, a 5-HT2A receptor agonist following LPS treatment. Body weight change and locomotor-activity were also observed.2. DOI (1 mg/kg)-induced WDS significantly decreased after 400 or 1000 mug/kg LPS treatment compared with that of control rats 1 and 3 hr alter injection, and WDS completely recovered 8 hr after LPS treatment. Treatment with10 mg/kg indomethacin (IND) or 1 mg/kg naltrexone (NLTX) canceled the effect of 400 mug/kg LPS on DOI-induced WDS.3. Body weight decrease was significantly greater in LPS-treated rats compared with control rats 3, 5 and 8 hr after treatment. Treatment with IND(10; mg/kg) significantly recovered the reduction in body weight induced by 400 mug/kg LPS. Treatment with NLTX (1 mg/kg) also prevented the LPS effect on body weight decrease.4. Eight hr after treatment with LPS (400 mug/kg), the rats showed significant attenuation of locomotor activity. IND (10mg/kg) treatment abolished the inhibitory effect of LPS on locomotor activity, and NLTX (1 mg/kg) also improved the decrease in locomotion 8 hr after LPS treatment.5. Plasma tumor necrosis factor (TNF)-alpha concentration dramatically increased 1 hr after the injection of 400 mug/kg LPS, and returned almost to the basal level 3 hr later. Next, rats were injected with 50 mug/kg TNF-alpha intraperitoneally, and body weight change and DOI-induced WDS was determined 3 hr after TNF-ol injection. Body weight loss was significantly greaterin rats treated with TNF-alpha. On the other hand, DOI-induced WDS was notaltered when rats were treated with TNF-alpha.6. These results suggest that acute treatment with LPS inhibited 5-HT2A receptor-mediated behavior via cyclooxygenase and opioid receptor activation,but that the inhibition of the WDS by LPS appears to be independent of TNF-alpha production.6. These results suggest that acute treatment with LPS inhibited 5-HT2A receptor-mediated behavior via cyclooxygenase and opioid receptor activation,but that the inhibition of the WDS by LPS appears to be independent of TNF-alpha production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:20:43