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Titolo:
Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members
Autore:
Friedland, RP; Fritsch, T; Smyth, KA; Koss, E; Lerner, AJ; Chen, CH; Petot, GJ; Debanne, SM;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Neurol, Lab Neurogeriatr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Nutr, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Alzheimer Ctr, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 r Ctr, Cleveland, OH 44106 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 6, volume: 98, anno: 2001,
pagine: 3440 - 3445
SICI:
0027-8424(20010313)98:6<3440:PWADHR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE DECLINE; DEFINED POPULATION; AFRICAN-AMERICANS; APOLIPOPROTEIN-E; OLDER PERSONS; EDUCATION; DEMENTIA; LIFE; PREVALENCE; RISK;
Keywords:
case-control study; dementia; epidemiology; leisure; recreation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Friedland, RP Case Western Reserve Univ, Sch Med, Dept Neurol, Lab Neurogeriatr, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
R.P. Friedland et al., "Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members", P NAS US, 98(6), 2001, pp. 3440-3445

Abstract

The development of Alzheimer's disease (AD) later in life may be reflective of environmental factors operating over the course of a lifetime. Educational and occupational attainments have been found to be protective against the development of the disease but participation in activities has receivedlittle attention. In a case-control study, we collected questionnaire dataabout 26 nonoccupational activities from ages 20 to 60. Participants included 193 people with probable or possible AD and 358 healthy control-group members. Activity patterns for intellectual, passive, and physical activities were classified by using an adaptation of a published scale in terms of "diversity" (total number of activities), "intensity" (hours per month), and"percentage intensity" (percentage of total activity hours devoted to eachactivity category). The control group was more active during midlife than the case group was for all three activity categories, even after controlling for age, gender, income adequacy, and education. The odds ratio for AD inthose performing less than the mean value of activities was 3.85 (95% confidence interval: 2.65-5.58, P < 0.001). The increase in time devoted to intellectual activities from early adulthood (20-39) to middle adulthood (40-60) was associated with a significant decrease in the probability of membership in the case group. We conclude that diversity of activities and intensity of intellectual activities were reduced in patients with AD as compared with the control group. These findings may be because inactivity is a risk factor for the disease or because inactivity is a reflection of very early subclinical effects of the disease, or both.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 12:37:17