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Titolo:
Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat
Autore:
Buwalda, B; Felszeghy, K; Horvath, KM; Nyakas, C; de Boer, SF; Bohus, B; Koolhaas, JM;
Indirizzi:
Univ Groningen, Dept Anim Physiol, NL-9750 AA Haren, Netherlands Univ Groningen Haren Netherlands NL-9750 AA L-9750 AA Haren, Netherlands Haynal Univ Hlth Sci, Div Cent Res, Budapest, Hungary Haynal Univ Hlth Sci Budapest Hungary , Div Cent Res, Budapest, Hungary
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 3, volume: 72, anno: 2001,
pagine: 349 - 354
SICI:
0031-9384(200102)72:3<349:TASDOC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; GLUCOCORTICOID RECEPTORS; FAST FEEDBACK; STRESS; ACTIVATION; HIPPOCAMPUS; EXPRESSION; DECREASE; ANXIETY; SYSTEMS;
Keywords:
glucocorticoid receptors; mineralocorticoid receptors; stress; corticosterone; pituitary; hypothalamus; hippocampus; septum; parietal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Buwalda, B Univ Groningen, Dept Anim Physiol, POB 14, NL-9750 AA Haren, Netherlands Univ Groningen POB 14 Haren Netherlands NL-9750 AA Netherlands
Citazione:
B. Buwalda et al., "Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat", PHYSL BEHAV, 72(3), 2001, pp. 349-354

Abstract

The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress. One week after defeat, the binding capacity of GRs wasdecreased in the hippocampus and the hypothalamus while no changes were observed in the parietal cortex and the pituitary. The number of MRs remainedat the same level as in undefeated rats. Three weeks postdefeat, the initially down-regulated GR returned to baseline level in the hippocampus and the hypothalamus. However, GR binding was now decreased in the parietal cortex,Severe down-regulation of MRs was detected in the hippocampal and septal tissue. The results show that brief but intense stress like social defeat induces a long-lasting down-regulation of corticosteroid receptors and that the temporal dynamics of these changes are not only differential for GRs and MRs but also for brain sites. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/12/18 alle ore 00:22:10