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Titolo:
Influence of coadministration of fluoxetine on cisapride pharmacokinetics and QTc intervals in healthy volunteers
Autore:
Zhao, QY; Wojcik, MA; Parier, JL; Pesco-Koplowitz, L;
Indirizzi:
Janssen Res Fdn, Titusville, NJ 08560 USA Janssen Res Fdn Titusville NJ USA 08560 Res Fdn, Titusville, NJ 08560 USA
Titolo Testata:
PHARMACOTHERAPY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 149 - 157
SICI:
0277-0008(200102)21:2<149:IOCOFO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX DISEASE; SEROTONIN REUPTAKE INHIBITORS; DEPRESSION; DRUG; PHARMACOLOGY; SAFETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, QY Janssen Res Fdn, 1125 Trenton Harbourton Rd, Titusville, NJ 08560USA Janssen Res Fdn 1125 Trenton Harbourton Rd Titusville NJ USA 08560
Citazione:
Q.Y. Zhao et al., "Influence of coadministration of fluoxetine on cisapride pharmacokinetics and QTc intervals in healthy volunteers", PHARMACOTHE, 21(2), 2001, pp. 149-157

Abstract

Study Objective. To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. Design. Open-label, three-phase, sequential studySetting. Clinical research center. Subjects. Twelve healthy male volunteers. Interventions. Each subject was treated according to the following sequence: baseline; phase 1 (days 1-6). cisapride 10 mg 4 times/day; washout (days7-13); phase 2 (days 14-44): fluoxetine 20 mg/day; and phase 3 (days 45-52): cisapride 10 mg 4 times/day (days 45-51) plus fluoxetine 20 mg/day (days45-52). Measurements and Main Results. Blood samples were drawn and 12-lead electrocardiograms performed at specified time points after the last morning doseof cisapride in phases 1 and 3. Blood samples also were taken before morning doses on the 3rd, 4th, and 5th days of phases 1 and 3, Electrocardiograms were done at baseline and on the last day of the washout period and phase2. Coadministration of fluoxetine significantly decreased cisapride plasmaconcentrations. There were no clinically significant changes in corrected QT intervals during administration of cisapride alone or with fluoxetine. Cisapride was well tolerated when administered alone or with fluoxetine. Conclusion. Cisapride can be administered safely to patients receiving lowtherapeutic dosages of fluoxetine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:19:19