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Titolo:
Serial changes in levels of IL-6 and IL-1 beta in premature infants at risk for bronchopulmonary dysplasia
Autore:
Kazzi, SNJ; Romero, R; McLaughlin, K; Ager, J; Janisse, J;
Indirizzi:
Wayne State Univ, Sch Med, Dept Pediat, Hutzel Hosp, Detroit, MI 48201 USAWayne State Univ Detroit MI USA 48201 Hutzel Hosp, Detroit, MI 48201 USA NICHHD, Perinatol Res Branch, NIH, Bethesda, MD 20892 USA NICHHD BethesdaMD USA 20892 atol Res Branch, NIH, Bethesda, MD 20892 USA Wayne State Univ, Sch Med, Hutzel Hosp, Ctr Hlth Effectiveness Res, Detroit, MI USA Wayne State Univ Detroit MI USA Hlth Effectiveness Res, Detroit, MI USA
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 220 - 226
SICI:
8755-6863(200103)31:3<220:SCILOI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LUNG-DISEASE; RESPIRATORY-DISTRESS SYNDROME; BRONCHOALVEOLAR LAVAGE FLUID; TUMOR-NECROSIS-FACTOR; PRETERM INFANTS; INFLAMMATORY MEDIATORS; DEXAMETHASONE THERAPY; SECRETORY COMPONENT; CONTROLLED TRIAL; CYTOKINE LEVELS;
Keywords:
bronchopulmonary dysplasia; inflammatory mediators; cytokines; neonatal lung inflammation; prematurity; neonatology; chronic lung disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kazzi, SNJ Wayne State Univ, Sch Med, Dept Pediat, Hutzel Hosp, 4707 St Antoine Blvd,Detroit, MI 48201 USA Wayne State Univ 4707 St Antoine Blvd Detroit MI USA 48201 USA
Citazione:
S.N.J. Kazzi et al., "Serial changes in levels of IL-6 and IL-1 beta in premature infants at risk for bronchopulmonary dysplasia", PEDIAT PULM, 31(3), 2001, pp. 220-226

Abstract

The aim of this study was to define the inflammatory changes occurring in the lungs of infants at risk for bronchopulmonary dysplasia (BPD) over the first 28 days of life, and to define an optimal strategy for steroids therapy in the prevention of BPD. We measured levels of interleukin-6 (IL-6) andinterleukin-l beta (IL-1 beta) in tracheal aspirate (TA) samples and bloodof premature infants with severe respiratory distress syndrome RDS (n=45) on the first day of life prior to initiation of surfactant therapy and on days 5-7, 12-14, 19-21, and 26-28. Levels of IL-6 and IL-1 beta were determined with a commercially available enzyme-linked immunoassay. Logistic regression analyses were performed in order to examine differences in trends in levels of IL-6 and IL-1 beta between groups of infants. Infants were divided into group I (n = 30, FiO(2) less than or equal to 0.35 at 28 days) and group II (n=15, FiO(2)>0.35 based on their likelihood of developing BPD at 36 weeks postconceptional age (PCA). The infants were comparable with respect to mean (+/-SEM) birth weight (895+/-33 g vs. 900 +/- 40 g), gestational age (27 +/- 0.38 weeks vs. 27 +/- 0.54 weeks), and severity of respiratory illness at entry into the study (mean airway pressure: 12 +/- 1 cmH(2)O vs, 12 +/- 1 cmH(2)O, and oxygen index: 15 +/- 2 vs. 19 +/- 4) (group I vs. group II, respectively), Logistic regression analyses failed to reveal any significant differences in linear trends of levels of IL-6 and IL-1 beta in TA samples between both groups of infants. No particular pattern of change in levels of IL-6 or IL-1 beta couldbe identified among groups of infants. Levels of IL-6 and IL-1 beta in TA samples on the first day of life failed to predict the need for FiO(2) > 0.35 at 28 days of age. We could not identity an increasing trend or a specific pattern of changesin postnatal levels of IL-6 or IL-1 beta in TA samples of infants who wereat greater risk of developing BPD at 36 weeks PCA compared to infants who were not.

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Documento generato il 06/04/20 alle ore 08:17:08