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Titolo:
Evidence of early systemic activation and transendothelial migration of neutrophils in neonates with severe respiratory distress syndrome
Autore:
Sarafidis, K; Drossou-Agakidou, V; Kanakoudi-Tsakalidou, F; Taparkou, A; Tsakalidis, C; Tsandali, C; Kremenopoulos, G;
Indirizzi:
Aristotelian Univ Salonika, Hippokratio Gen Hosp, Dept Neonatol, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece Aristotelian Univ Salonika, Dept Pediat A, Hippokratio Gen Hosp, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 214 - 219
SICI:
8755-6863(200103)31:3<214:EOESAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; CIRCULATING POLYMORPHONUCLEAR LEUKOCYTES; SOLUBLE L-SELECTIN; BRONCHOPULMONARY DYSPLASIA; ADHESION MOLECULES; ELASTASE RELEASE; CONTROLLED TRIAL; PRETERM INFANTS; BURST ACTIVITY; CORD-BLOOD;
Keywords:
neonates; respiratory distress syndrome; neutrophils; respiratory burst activity; CD11b; interleukin-6; granulocyte colony-stimulating factor; sL-selectin; cytokines; inflamation; brinchopulmonary dysplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Drossou-Agakidou, V Glinou 28, Salonika 54352, Greece Glinou 28 SalonikaGreece 54352 lonika 54352, Greece
Citazione:
K. Sarafidis et al., "Evidence of early systemic activation and transendothelial migration of neutrophils in neonates with severe respiratory distress syndrome", PEDIAT PULM, 31(3), 2001, pp. 214-219

Abstract

Several observations imply that the early inflammatory response involving activated neutrophils, tissue macrophages, and cytokines plays an importantrole in the pathogenesis of neonatal respiratory distress syndrome (RDS) and progression to bronchopulmonary dysplasia (BPD). The aim of this study was to test the hypothesis that changes in circulating neutrophil number andfunction and plasma levels of cytokines, consistent with neutrophil activation and migration to the tissues, occur during the early stages of neonatal RDS. For this purpose we measured peripheral blood levels of certain immunological parameters that promote neutrophil activation and transendothelial migration, Twenty preterm neonates with severe RDS and 20 healthy infantsmatched for gestational age were the subjects. The absolute neutrophil count (ANC), and plasma levels of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and sl-selectin using an enzyme-linked immunosorbent assay (ELISA), neutrophil CD11b expression, and respiratory burst activity (RBA) using flow cytometry, were measured within 24 h after birth. The two groups were comparable regarding perinatal characteristics. None of the neonates studied had any clinical or laboratory evidence of infectionby the time of blood sampling. The immunological investigation showed thatthe RDS neonates had significantly lower ANC (P= 0.032), higher expressionof the CD11b on neutrophils (P= 0.0065), and higher G-CSF and IL-6 plasma levels (P= 0.0047 and P< 0.0001, respectively) in comparison to healthy preterm neonates. The neutrophil RBA and plasma sl-selectin levels did not differ significantly between the two groups. We conclude that in neonates with severe RDS, there is evidence of a systemic neutrophil activation early in the course of the disease, supporting the view of a contributing role of activated neutrophils in the pathogenesis of RDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:33:34