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Titolo:
Cellular and noncellular components of bronchoalveolar lavage fluid in HIV-1-infected children with radiological evidence of interstitial lung damage
Autore:
Midulla, F; Strappini, P; Sandstrom, T; Bjermer, L; Falasca, C; Capocaccia, P; Catania, S; Soldi, E; Villa, MP; Ronchetti, R;
Indirizzi:
Univ Rome La Sapienza, Inst Pediat, Biochem Lab, Rome, Italy Univ Rome La Sapienza Rome Italy Inst Pediat, Biochem Lab, Rome, Italy Univ Rome La Sapienza, Inst Pediat, Dept Pediat 2, Rome, Italy Univ Rome La Sapienza Rome Italy nst Pediat, Dept Pediat 2, Rome, Italy Univ Umea Hosp, Dept Lung Med, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 , Dept Lung Med, S-90185 Umea, Sweden Univ Trondheim Hosp, Dept Lung Med, Trondheim, Norway Univ Trondheim HospTrondheim Norway , Dept Lung Med, Trondheim, Norway Univ Rome La Sapienza, Inst Pediat, Dept Pediat Radiol, Rome, Italy Univ Rome La Sapienza Rome Italy ediat, Dept Pediat Radiol, Rome, Italy Univ Rome La Sapienza, Dept Infect Dis, Rome, Italy Univ Rome La SapienzaRome Italy Sapienza, Dept Infect Dis, Rome, Italy
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 205 - 213
SICI:
8755-6863(200103)31:3<205:CANCOB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-INFECTED PATIENTS; PNEUMOCYSTIS-CARINII PNEUMONITIS; ACTIVE PULMONARY SARCOIDOSIS; ALVEOLAR MACROPHAGES; HYALURONIC-ACID; AIDS PATIENTS; DISEASE; FIBRONECTIN; CELLS; INTERLEUKIN-2;
Keywords:
bronchoalveolar lavage; cellular and noncellular components; AIDS; children; human immunodeficiency virus; interstitial lung disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Midulla, F Ist Clin Pediat, Cattedra Clin Pediat 2, Viale Regina Elena 324, I-00161 Rome, Italy Ist Clin Pediat Viale Regina Elena 324 Rome Italy I-00161 taly
Citazione:
F. Midulla et al., "Cellular and noncellular components of bronchoalveolar lavage fluid in HIV-1-infected children with radiological evidence of interstitial lung damage", PEDIAT PULM, 31(3), 2001, pp. 205-213

Abstract

Children with acquired immune deficiency syndrome (AIDS) commonly have recurrent infectious and noninfectious lung complications that ultimately end in death. To study the intensity of alveolar inflammation and to evaluate the clinical utility of bronchoalveolar lavage (BAL) in children with HIV-1 infections, we retrospectively analyzed differential cell counts, lymphocyte subsets, and fibronectin and hyaluronic acid concentrations in BAL fluid of 18 HIV-1-positive children (9 boys, mean age 3.5 years, range 5 months-8years) with radiological evidence of interstitial lung disease, and 19 control children who had undergone BAL for clinical indications not involving the lung parenchyma (13 boys, mean age 3 years, range 2 months-14 years). BAL fluid from 89% of the HIV-I infected children showed CD8+ve lymphocytic alveolitis expressing HLA-DR, CD54, and CD 69 antigens. BAL fluid from HIV-infected patients typically contained markedly increased percentages and numbers of lymphocytes (P < 0.0001) and eosinophils (P < 0.04) and significantly higher concentrations of albumin (P < 0.05) and fibronectin (P < 0.0006) than fluids from control children. Whereas BAL cellular components did not differ in P, carinii-positive and P, carinii-negative HIV-l-infected children, fibronectin concentrations were significantly higher in P. carinii-positive than negative children. BAL cell differentials and noncellular components were related neither to severity of disease nor to patients' disease progression. These findings indicate that BAL is useful in studying the intensity of lung inflammation in children with HIV-1 infections and radiologically documented interstitial lung disease, but provides no information on the subsequent clinical course.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:52:01