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Titolo:
Epidemiology of herpes simplex virus in children by detection of specific antibodies in saliva
Autore:
Spicher, VM; Bouvier, P; Schlegel-Haueter, SE; Morabia, A; Siegrist, CA;
Indirizzi:
Youth Hlth Serv, Geneva, Switzerland Youth Hlth Serv Geneva SwitzerlandYouth Hlth Serv, Geneva, Switzerland Univ Hosp Geneva, Div Clin Epidemiol, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland Clin Epidemiol, Geneva, Switzerland Univ Hosp Geneva, Dept Pediat, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland a, Dept Pediat, Geneva, Switzerland Univ Hosp Geneva, Dept Pathol, Geneva, Switzerland Univ Hosp Geneva Geneva Switzerland a, Dept Pathol, Geneva, Switzerland
Titolo Testata:
PEDIATRIC INFECTIOUS DISEASE JOURNAL
fascicolo: 3, volume: 20, anno: 2001,
pagine: 265 - 272
SICI:
0891-3668(200103)20:3<265:EOHSVI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; EPSTEIN-BARR-VIRUS; CAPTURE RADIOIMMUNOASSAY; HUMAN HERPESVIRUSES; ENZYME-IMMUNOASSAY; SCHOOL OUTBREAK; HEPATITIS-A; DAY-CARE; TYPE-1; INFECTION;
Keywords:
herpes simplex; epidemiology; children; saliva antibodies; prevalence; determinants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Siegrist, CA Ctr Med Univ Geneva, Ctr Vaccinol & Neonatal Immunol, Dept Pediat, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland Ctr Med Univ Geneva Rue Michel-Servet 1 Geneva Switzerland CH-1211
Citazione:
V.M. Spicher et al., "Epidemiology of herpes simplex virus in children by detection of specific antibodies in saliva", PEDIAT INF, 20(3), 2001, pp. 265-272

Abstract

Objectives. To facilitate the study of the prevalence of herpes simplex virus (HSV) infection and its determinants in children, we developed a noninvasive saliva test. Methods. A capture enzyme-linked immunosorbent assay (ELISA) for the detection of IgG to HSV in saliva was developed, validated against a commercial serum ELISA in 110 children and 187 adults and used in a cross-sectional population-based study including 2048 children ages 1 to 17 years, recruited in day-care centers and schools of Geneva, Switzerland. Demographic and socioeconomic determinants of HSV prevalence were studied. Results. The sensitivity and specificity of the saliva assay were 94.1 and95.5%, respectively, compared with the commercial serum ELISA. Participation in the cross-sectional study was 86.6%. The overall prevalence of anti-HSV IgG was 23.9%. It increased with age up to 7 years, reaching a plateau at 35% without evidence for day-care or school transmission. The main determinants of prevalence were region of national origin and parents' professional category. Conclusions. This new saliva-based assay proved its feasibility in the first population-based study of HSV prevalence in children that uses saliva, confirmed its validity by identifying determinants of prevalence consistent with previous reports and yielded new information, such as the lack of influence of day-care attendance, in the population studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:38:07