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Titolo:
Pathophysiology of otosclerosis
Autore:
Chole, RA; McKenna, M;
Indirizzi:
Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Otolaryngol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Mol Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 l Pharmacol, St Louis, MO 63110 USA Harvard Univ, Sch Med, Dept Otolaryngol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Dept Otolaryngol, Boston, MA 02115 USA
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 249 - 257
SICI:
1531-7129(200103)22:2<249:POO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CAMURATI-ENGELMANN DISEASE; SENSORINEURAL HEARING-LOSS; SODIUM-FLUORIDE TREATMENT; II COLLAGEN AUTOIMMUNITY; PAGETS-DISEASE; TEMPORAL BONE; MIDDLE-EAR; ACTIVE OTOSCLEROSIS; OTIC CAPSULE;
Keywords:
otosclerosis; hearing loss; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Chole, RA Washington Univ, Sch Med, Dept Otolaryngol, Campus Box 8115,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Campus Box 8115,660 S Euclid Ave St Louis MO USA 63110
Citazione:
R.A. Chole e M. McKenna, "Pathophysiology of otosclerosis", OTOL NEURO, 22(2), 2001, pp. 249-257

Abstract

Objective: To review current knowledge of the pathophysiology of otosclerosis and to review hypotheses for the amelioration of this disease. Data Sources: Review of the literature and experimental observations by the authors. Conclusions: Otosclerosis is a localized disease of bone remodeling withinthe otic capsule of the human temporal bone. Unlike other similar bone diseases, it does not occur outside of the temporal bone. These lesions seem to begin by resorption of stable otic capsule bone in adults, followed by a reparative phase with bone deposition. There are clearly genetic factors that lead to this disease, but measles virus infection and autoimmunity also may play contributing roles. Surgical correction of the conductive hearing loss is highly effective, but nonsurgical intervention has not yet been shown to prevent or slow the disease. Of the factors that may inhibit this process, fluorides, cytokine inhibitors, and bisphosphonates, third-generationbisphosphonates appear to hold the most promise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:11:35