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Titolo:
Effect of chemical sympathectomy with 6-hydroxydopamine on osteoclast activity in the gerbilline middle ear bulla
Autore:
Sherman, BE; Chole, RA;
Indirizzi:
Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, St Louis, MO USA Washington Univ St Louis MO USA yngol Head & Neck Surg, St Louis, MO USA Univ Calif Davis, Sch Med, Dept Otolaryngol Head & Neck Surg, Sacramento, CA 95817 USA Univ Calif Davis Sacramento CA USA 95817 k Surg, Sacramento, CA 95817 USA
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 237 - 241
SICI:
1531-7129(200103)22:2<237:EOCSW6>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-RESORPTION INVITRO; IN-VIVO; MEDIATED MECHANISM; INTERFERON-GAMMA; SENSORY NEURONS; EXPRESSION;
Keywords:
bone resorption; 6-hydroxydopamine; middle ear; Mongolian gerbil; sympathectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Chole, RA Washington Univ, Sch Med, Dept Otolaryngol, Campus Box 8115,660 S Euclid Ave, St Louis, MO 63130 USA Washington Univ Campus Box 8115,660 S Euclid Ave St Louis MO USA 63130
Citazione:
B.E. Sherman e R.A. Chole, "Effect of chemical sympathectomy with 6-hydroxydopamine on osteoclast activity in the gerbilline middle ear bulla", OTOL NEURO, 22(2), 2001, pp. 237-241

Abstract

Hypothesis: Chemical sympathectomy with 6-hydroxydopamine (HDA) increases middle ear bulla bone resorption in the Mongolian gerbil. Background: Many diseases of the middle ear have pathologic processes linked to abnormal bone remodeling. Numerous factors controlling bone remodeling have been identified. An understanding of these factors and their role inpathologic remodeling is therefore essential. Sympathectomy, induced both surgically and pharmaceutically, is known to increase middle ear bone resorption. suggesting a role for the central nervous system in bone metabolism. This effect, however, may be confounded by hemodynamic changes induced by hemicranial surgical sympathectomy or by uncertainty in the action of pharmaceutical agents on the sympathetic nervous system. In this experiment, a third modality with unique properties, chemical sympathectomy with HDA, was used to quantify further the effect of sympathectomy on middle ear bone remodeling. Methods: Eight gerbils designated experimental received in traperitoneal injections of HDA (75 mg/kg) for 1 week, whereas eight animals designated control received similar injections of saline. One week after injections, theanimals were euthanized and bulla bone samples were analyzed histomorphometrically to determine osteoclastic activity. In addition, to assess for anydirect effects on bone metabolism, the activity of HDA was determined in vitro using the calvarial calcium re lease assay. Results: The in vitro study found HDA to have no direct stimulatory activity on calcium release. The in vivo study showed HDA to increase osteoclastic activity significantly in middle ear bone. Conclusion: HDA-induced sympathectomy increases bone resorption in gerbilline middle ear bone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 13:56:28