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Titolo:
Acoustic neuroma: Predominance of Antoni type B cells in tumors of patients with vestibular paresis
Autore:
Stipkovits, EM; Graamans, K; Jansen, GH; Velthof, MAM;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Pathol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
OTOLOGY & NEUROTOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 215 - 217
SICI:
1531-7129(200103)22:2<215:ANPOAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE; HISTOPATHOLOGY;
Keywords:
acoustic neuroma; vestibular diseases; histology; schwannoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Graamans, K Univ Utrecht, Med Ctr, Dept Otorhinolaryngol, G05-129,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht G05-129,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
E.M. Stipkovits et al., "Acoustic neuroma: Predominance of Antoni type B cells in tumors of patients with vestibular paresis", OTOL NEURO, 22(2), 2001, pp. 215-217

Abstract

Objective: This study aimed to investigate whether in patients with acoustic neuroma (AN), the presence or absence of vestibular symptoms is related to the histologic characteristics of the tumor. Study Design: The study design was a retrospective clinical study. Setting: The study was conducted at a tertiary referral center. Patients: A group of eight patients with unilateral AN and normal vestibular function was compared with a group of AN patients, matched for tumor size, with vestibular paresis. Methods: The methods were vestibular examination of the patients and morphometric analysis of the histologic specimens of their tumors. Main Outcome Measures: The outcomes were measured by vestibular function and by the relative quantity of Antoni type A or type B cell tissue. Results: The tumors of patients with vestibular paresis appeared to contain significantly more Antoni B cells and fewer Antoni A cells than did the tumors of patients with normal vestibular function. Conclusions: Besides morphologic differences, type B cells may display a distinct behavior compared with type A cells. Presumably, in AN patients thedevelopment of a vestibular paresis appears to be related to the biologic activity of type B cells in the tumor.

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Documento generato il 15/07/20 alle ore 14:41:07