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Titolo:
Asymmetric synthesis of the northern half C1-C16 of the bryostatins
Autore:
Vakalopoulos, A; Lampe, TFJ; Hoffmann, HMR;
Indirizzi:
Univ Hannover, Dept Organ Chem, D-30167 Hannover, Germany Univ Hannover Hannover Germany D-30167 n Chem, D-30167 Hannover, Germany
Titolo Testata:
ORGANIC LETTERS
fascicolo: 6, volume: 3, anno: 2001,
pagine: 929 - 932
SICI:
1523-7060(20010322)3:6<929:ASOTNH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL EVALUATION; C(17)-C(27) FRAGMENT; SEGMENT; ANALOGS; TRIACETOXYBOROHYDRIDE; DESYMMETRIZATION; KETONES; RING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffmann, HMR Univ Hannover, Dept Organ Chem, Schneiderberg 1 B, D-30167 Hannover, Germany Univ Hannover Schneiderberg 1 B Hannover Germany D-30167 ny
Citazione:
A. Vakalopoulos et al., "Asymmetric synthesis of the northern half C1-C16 of the bryostatins", ORG LETT, 3(6), 2001, pp. 929-932

Abstract

[GRAPHICS]Starting from 8-oxabicyclo[3.2.1]oct-6-en-3-one and racemic 2,2-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one the C1-C16 segment of the bryostatins has been synthesized in 30 steps and 9% overall yield (17 steps longest linear sequence), Fragment coupling by dithiane strategy and protecting group manipulations provided an advanced chemodifferentiated northern half segment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:25:12