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Titolo:
Synthesis of an eight-membered cyclic pseudo-dipeptide using ring closing metathesis
Autore:
Creighton, CJ; Reitz, AB;
Indirizzi:
RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA RW Johnson Pharmaceut Res Inst Spring House PA USA 19477 se, PA 19477 USA
Titolo Testata:
ORGANIC LETTERS
fascicolo: 6, volume: 3, anno: 2001,
pagine: 893 - 895
SICI:
1523-7060(20010322)3:6<893:SOAECP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLEFIN-METATHESIS; ORGANIC-SYNTHESIS; NEW-GENERATION; CATALYST; PEPTIDES; ANALOGS; BEARING; LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Reitz, AB RW Johnson Pharmaceut Res Inst, Welsh & McKean Rd, Spring House,PA 19477 USA RW Johnson Pharmaceut Res Inst Welsh & McKean Rd Spring HousePA USA 19477
Citazione:
C.J. Creighton e A.B. Reitz, "Synthesis of an eight-membered cyclic pseudo-dipeptide using ring closing metathesis", ORG LETT, 3(6), 2001, pp. 893-895

Abstract

[GRAPHICS]Ring closing metathesis of diallylglycine 6 provided cyclic Z-olefin 7 in 80% yield, The reaction was promoted by substitution of the amide nitrogen with the 2,4-dimethoxybenzyl group allowing for the required cis diallylglycine amide rotamer, Removal of the protecting groups provided cyclic dipeptide 2, a constrained scaffold useful in peptidomimetic research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:19:14