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Titolo:
Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients
Autore:
Ammatuna, P; Campisi, G; Giovannelli, L; Giambelluca, D; Alaimo, C; Mancuso, S; Margiotta, V;
Indirizzi:
Univ Palermo, Dept Hyg & Microbiol, I-90133 Palermo, Italy Univ Palermo Palermo Italy I-90133 g & Microbiol, I-90133 Palermo, Italy Univ Palermo, Dept Oral Med, I-90133 Palermo, Italy Univ Palermo PalermoItaly I-90133 Dept Oral Med, I-90133 Palermo, Italy Univ Palermo, Reg Reference Ctr AIDS, I-90133 Palermo, Italy Univ PalermoPalermo Italy I-90133 ence Ctr AIDS, I-90133 Palermo, Italy
Titolo Testata:
ORAL DISEASES
fascicolo: 1, volume: 7, anno: 2001,
pagine: 34 - 40
SICI:
1354-523X(200101)7:1<34:POEVCA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; POLYMERASE CHAIN-REACTION; HAIRY LEUKOPLAKIA; EPITHELIAL-CELLS; PREVALENCE; DNA; LESIONS; MANIFESTATIONS; POPULATION; ULCERS;
Keywords:
EBV-DNA; CMV-DNA; HPV-DNA; oral epithelium; immunodeficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Margiotta, V Ist Odontostomatol, Policlin P Giaccone, Via Vespro 129, I-90127 Palermo, Italy Ist Odontostomatol Via Vespro 129 Palermo Italy I-90127taly
Citazione:
P. Ammatuna et al., "Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients", ORAL DIS, 7(1), 2001, pp. 34-40

Abstract

OBJECTIVES: To determine the prevalence of EBV-DNA, CMV-DNA and HPV-DNA inoral healthy mucosa of HIV-infected and renal transplant patients. To associate the detection of viral genomes with laboratory parameters of immunodeficiency, gender, antiretroviral and immunosuppressive therapy. DESIGN: A cross-sectional analysis of lingual and buccal cytobrushings from HIV-infected and renal transplant patients. SUBJECTS AND METHODS: Lingual and buccal cytobrushings were obtained from clinically normal oral mucosa of 57 HIV+, 40 renal transplant patients and 30 healthy uninfected controls, all matched for age at baseline of examination. Presence of EBV-, CMV- and HPV-DNA was assessed by polymerase chain reaction (PCR). We evaluated their association, in HIV+ subjects, with gender, CD4(+) cell count, HIV-RNA load, and antiretroviral therapy; and in renaltransplant patients, with gender, CD4/CD8 ratio, and immunosuppressive therapy. Data were managed and analysed by Epi-Info 6.0. RESULTS: EBV-DNA was detected in 42.1% of HIV+ (24/57), in 65.0% of transplant patients (26/40), and in 16.6% of controls (5/30) (P = 0.03 and P = 0.0001, respectively). Furthermore, mate gender in HIV+ group was found to besignificantly associated with the presence of EBV-DNA (P = 0.02) vs females, after adjusting for CD4(+) cell count and HIV-RNA road. CMV- and HPV-DNAwere detected in 3.5% and 7.0% of HIV+, and in none and 20.0% of transplant patients, respectively. No relationship was found between the epithelial detection of these two viruses and any parameter evaluated. CONCLUSIONS: EBV genome was significantly detected in clinically normal oral mucosa of renal transplant and HIV+ patients. A significant gender association was found among HIV+, suggesting that oral hairy leukoplakia (OHL) is more likely to occur in HIV+ men than women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:47:11