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Titolo:
Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells
Autore:
Slack, JK; Adams, RB; Rovin, JD; Bissonette, EA; Stoker, CE; Parsons, JT;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Dept Surg, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Dept Hlth Evaluat Sci, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
ONCOGENE
fascicolo: 10, volume: 20, anno: 2001,
pagine: 1152 - 1163
SICI:
0950-9232(20010308)20:10<1152:AITFAK>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; SRC FAMILY KINASES; SUBSTRATE P130(CAS); DROSOPHILA HOMOLOG; IN-VIVO; PHOSPHORYLATION; INTEGRIN; CRK; ACTIVATION; PAXILLIN;
Keywords:
focal adhesion kinase; Src; cell migration; prostate; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Parsons, JT Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Box 441, Charlottesville, VA 22908 USA Univ Virginia Box 441 Charlottesville VA USA 22908 A 22908 USA
Citazione:
J.K. Slack et al., "Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells", ONCOGENE, 20(10), 2001, pp. 1152-1163

Abstract

Focal adhesion kinase (FAK) has been implicated in the regulation of cell migration. In addition, FAK expression is:increased in a number of highly metastatic tumor cell lines. Therefore, we investigated the role of FAK in regulating migration of prostate carcinoma cell lines with increasing metastatic potential. We show that highly tumorigenic PC3 and DU145 cells exhibitintrinsic migratory capacity, while poorly tumorigenic LNCaP cells requirea stimulus to migrate, Increased metastatic potential of PC3 and DU145 cells correlates with increased FAK expression, overall tyrosine phosphorylation and activity, as measured by autophosphorylation of tyrosine 397, However, in PC3 and DU145 cells, FAK autophosphorylation is adhesion dependent whereas a second site of tyrosine phosphorylation, tyrosine 861, a Src specific site, is uncoupled from adhesion-dependent signaling events, Finally, inhibiting the FAK/Src signal transduction pathway by over expressing FRNK ((F) under bar ocal adhesion kinase-(R) under bar elated (N) under bar on-(K)under bar inase), an inhibitor of FAK activation, or treatment with PP2, aSrc family kinase-inhibitor, significantly inhibited migration of prostatecarcinoma cell lines, demonstrating that tumor cell migration continues tobe dependent on signals emanating from this pathway.

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Documento generato il 01/12/20 alle ore 07:35:09