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Titolo:
Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5
Autore:
Wilson, MD; Riemer, C; Martindale, DW; Schnupf, P; Boright, AP; Cheung, TL; Hardy, DM; Schwartz, S; Scherer, SW; Tsui, LC; Miller, W; Koop, BF;
Indirizzi:
Univ Victoria, Dept Biol, Ctr Environm Hlth, Victoria, BC V8W 3N5, Canada Univ Victoria Victoria BC Canada V8W 3N5 th, Victoria, BC V8W 3N5, Canada Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 n, University Pk, PA 16802 USA Hosp Sick Children, Dept Genet, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430USA Texas Tech Univ Lubbock TX USA 79430 Biol & Biochem, Lubbock, TX 79430USA
Titolo Testata:
NUCLEIC ACIDS RESEARCH
fascicolo: 6, volume: 29, anno: 2001,
pagine: 1352 - 1365
SICI:
0305-1048(20010315)29:6<1352:CAOTGA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOMIC SEQUENCE-ANALYSIS; ERYTHROPOIETIN GENE; TYROSINE KINASE; MOLECULAR-CLONING; MYELOID LEUKEMIAS; MEMBRANE-PROTEIN; MAMMALIAN GENOME; MESSENGER-RNA; CCG REPEATS; BAND 7Q22;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Koop, BF Univ Victoria, Dept Biol, Ctr Environm Hlth, POB 3020, Victoria, BC V8W 3N5, Canada Univ Victoria POB 3020 Victoria BC Canada V8W 3N5 V8W 3N5, Canada
Citazione:
M.D. Wilson et al., "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5", NUCL ACID R, 29(6), 2001, pp. 1352-1365

Abstract

Chromosome 7q22 has been the focus of many cytogenetic and,molecular studies aimed at delineating regions commonly deleted in myeloid leukemias and myelodysplastic syndromes. We have compared a gene-dense, CC-rich sub-regionof 7q22 with the orthologous region on mouse chromosome 5, A physical map of 640 kb of genomic DNA from mouse chromosome 5 was derived from a series of overlapping bacterial artificial chromosomes, A 296 kb segment from the physical map, spanning Ache to Tfr2, was Compared with 267 kb of human sequence. We identified a conserved linkage of 12 genes including an open reading frame flanked by Ache and Asr2, a novel cation-chloride cotransporter interacting protein Cip1, Ephb4, Zan and Perq1. While some of these genes have been previously described, in each case we present new data derived from-our comparative sequence analysis. Adjacent unfinished sequence data from the mouse contains an orthologous block of 10 additional genes including three novel cDNA sequences that we subsequently mapped to human 7q22, Methods for displaying; I comparative genomic information, including unfinished sequence data, are becoming increasingly:important. We supplement our printed comparative analysis with a new, Web-based program called Laj (local alignments with java). Laj provides interactive access to archived pairwise sequence alignments via the WWW, It displays synchronized views of a dot-plot, apercent identity plot, a nucleotide-level local alignment and a variety ofrelevant annotations. Our mouse-human comparison can be viewed at http://web.uvic.ca/similar to bioweb/laj.html. Laj is available at http://bio.cse.psu.edu/. along with online documentation and additional examples of annotated genomic regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:06:21