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Titolo:
Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity
Autore:
Daheron, L; Zenz, T; Siracusa, LD; Brenner, C; Calabretta, B;
Indirizzi:
Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel Canc Inst, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
NUCLEIC ACIDS RESEARCH
fascicolo: 6, volume: 29, anno: 2001,
pagine: 1308 - 1316
SICI:
0305-1048(20010315)29:6<1308:MCOIAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; OPEN READING FRAME; MESSENGER-RNA; PHILADELPHIA-CHROMOSOME; TRANSLATIONAL CONTROL; CELL LINE; TRANSFORMATION; EXPRESSION; INHIBITION; REQUIRES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Calabretta, B Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel CancInst, BluemleLife Sci Bldg,233 S 10th St,Room 630, Philadelphia, PA 19107 USA Thomas Jefferson Univ Bluemle Life Sci Bldg,233 S 10th St,Room 630 Philadelphia PA USA 19107
Citazione:
L. Daheron et al., "Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity", NUCL ACID R, 29(6), 2001, pp. 1308-1316

Abstract

Using the representation difference analysis technique, We have identifieda novel gene, Ian4, which is preferentially expressed in hematopoietic precursor 32D cells transfected with wild-type versus mutant forms of the Bcr/Abl oncogene, Ian4 expression was undetectable in 32D cells transfected with v-src, oncogenic Ha-ras or v-Abl, Murine Ian4 maps to chromosome 6, 25 cMfrom the centromere, The Ian4 mRNA-contains two open reading frames (ORFs)separated by 5 nt, The first ORF has the potential to encode for a polypeptide of 67 amino acids without apparent homology to known proteins. The second ORF encodes a protein of 301 amino acids with a GTP/ATB-binding site inthe N-terminus and a hydrophobic domain in the extreme C-terminus, The IAN-4 protein resides in the mitochondrial outer membrane and the last 20 amino acids are necessary for this localization, The IAN-4 protein has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated -nucleotide (IAN) family.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:49:00