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Titolo:
Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats
Autore:
Schioth, HB; Kakizaki, Y; Kohsaka, A; Suda, T; Watanobe, H;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 3, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan Uppsala Univ, BMC, Dept Neurosci, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 pt Neurosci, S-75124 Uppsala, Sweden Melacure Therapeut AB, Uppsala, Sweden Melacure Therapeut AB Uppsala Sweden cure Therapeut AB, Uppsala, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 687 - 690
SICI:
0959-4965(20010326)12:4<687:APPSLH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING-HORMONE; IN-VIVO; MELANOCORTIN RECEPTORS; MOLECULAR-CLONING; MC4 RECEPTOR; FOOD-INTAKE; PROTEIN; LEPTIN; ANTAGONIST; SECRETION;
Keywords:
Agrp; luteinizing hormone; melanocortin; prolactin surges;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Hirosaki Univ, Sch Med, Dept Internal Med 3, 5 Zaifu-cho, Hirosaki, Aomori0368216, Japan Hirosaki Univ 5 Zaifu-cho Hirosaki Aomori Japan 0368216 Japan
Citazione:
H.B. Schioth et al., "Agouti-related peptide prevents steroid-induced luteinizing hormone and prolactin surges in female rats", NEUROREPORT, 12(4), 2001, pp. 687-690

Abstract

We studied the effect of Agrp (agouti-related peptide) on LH (luteinizing hormone) and PRF (prolactin) surges in ovariectomized rats primed with estradiol and progesterone. The rats displayed characteristic LH and PRL surgesthat were completely abolished by starving. Injection of either 1 nmol or 3 nmol Agrp (83-132), a potent antagonist of the orexigenic MC3 and MC4 receptors, completely prevented both the LH and PRL surges. We also investigated the effects of either a single or double injection of anti-Agrp serum tofasted animals, which were without LH and PRL surges. A single injection of the antiserum was without effect, but the rats that received double injection of anti-Agrp serum partially reinstated both the LH and PRL surges. Although the onset of LH and PRL surges was significantly delayed in the double treated group, the highest levels of the surges for both hormones were statistically indistinguishable compared with the control group. These data give a clear indication that endogenous Agrp may be involved in LH and PRL surges during starvation, providing further evidence that the melanocortin system is important for these hormonal surges in female rats. NeuroReport 12:687-690 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:56:55