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Titolo:
Degeneration of nociceptive nerve terminals in human peripheral neuropathy
Autore:
Pan, CL; Lin, YH; Lin, WM; Tai, TY; Hsieh, ST;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Neurol, Taipei 10002, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 10002 t Neurol, Taipei 10002, Taiwan Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10002, Taiwan Natl TaiwanUniv Hosp Taipei Taiwan 10002 rnal Med, Taipei 10002, Taiwan Natl Taiwan Univ, Coll Med, Dept Anat & Cell Biol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 t & Cell Biol, Taipei 10018, Taiwan
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 787 - 792
SICI:
0959-4965(20010326)12:4<787:DONNTI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY NERVES; NORMATIVE DATA; SKIN; INNERVATION; POLYNEUROPATHY; REPEATABILITY; SENSATION; PGP-9.5;
Keywords:
epidermal nerve densities; immunocytochemistry; nerve degeneration; neuropathy; quantitative sensory testing; skin innervation; unmyelinated nerves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Hsieh, ST Natl Taiwan Univ Hosp, Dept Neurol, Taipei 10002, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 10002 Taipei 10002, Taiwan
Citazione:
C.L. Pan et al., "Degeneration of nociceptive nerve terminals in human peripheral neuropathy", NEUROREPORT, 12(4), 2001, pp. 787-792

Abstract

Patients with peripheral neuropathy have symptoms involving small-diameternociceptive nerves and elevated thermal thresholds. Nociceptive nerves terminate in the epidermis of the skin and are readily demonstrated with the neuronal marker, protein gene product 9.5 (PGP 9.5). To investigate the pathological characteristics of elevated thermal thresholds, we performed PGP 9.5 immunocytochemistry on 3 mm punch skin biopsies (the forearm and the leg) from 55 normal subjects and 35 neuropathic patients. Skin innervation wasevaluated by quantifying epidermal nerve densities. Epidermal nerve densities were reduced in neuropathic patients compared to normal subjects. Epidermal nerve densities were variably correlated with thermal thresholds. The proportion of neuropathic patients with reduced epidermal nerve densities was larger than the proportion of neuropathic patients with elevated thermalthresholds. These results indicated that degeneration of epidermal nerve terminals preceded the elevation of thermal thresholds. Skin biopsy togetherwith immunocytochemical demonstration of epidermal innervation offers a new approach to evaluate small-fiber sensory neuropathy. NeuroReport 12:787-792 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 30/09/20 alle ore 07:53:21