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Titolo:
Mitochondrial cytochrome c oxidase subunit III is selectively down-regulated by aluminum exposure in PC12S cells
Autore:
Bosetti, F; Solaini, G; Tendi, EA; Chikhale, EG; Chandrasekaran, K; Rapoport, SI;
Indirizzi:
NIA, Sect Brain Physiol & Metab, NIH, Bethesda, MD 20892 USA NIA BethesdaMD USA 20892 in Physiol & Metab, NIH, Bethesda, MD 20892 USA Scuola Super Studi Univ & Perfezionamento S Anna, I-56127 Pisa, Italy Scuola Super Studi Univ & Perfezionamento S Anna Pisa Italy I-56127 taly Univ Maryland, Sch Med, Dept Anesthesiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Anesthesiol, Baltimore, MD 21201 USA
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 721 - 724
SICI:
0959-4965(20010326)12:4<721:MCCOSI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; ALZHEIMERS-DISEASE; BRAIN ALUMINUM; RAT-BRAIN; NEUROBLASTOMA; TOXICITY; CALCIUM; EVENTS; SYSTEM; RNA;
Keywords:
aluminum; Alzheimer's disease; cytochrome c oxidase; dialysis dementia; gene expression; mitochondria; neurotoxicity; PC12S;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bosetti, F NIA, Sect Brain Physiol & Metab, NIH, 9000 Rockville Pike,Bldg 10,Rm 6N 202, Bethesda, MD 20892 USA NIA 9000 Rockville Pike,Bldg 10,Rm 6N 202 Bethesda MD USA 20892
Citazione:
F. Bosetti et al., "Mitochondrial cytochrome c oxidase subunit III is selectively down-regulated by aluminum exposure in PC12S cells", NEUROREPORT, 12(4), 2001, pp. 721-724

Abstract

Aluminum (Al) has been implicated in several neurological diseases including dialysis dementia and Alzheimer's disease (AD). One possible mechanism of Al neurotoxicity could involve alteration of mitochondrial gene expression. We exposed PC12 cells to 0.1-100 muM AlCl3 for 6 h at pH 7.4. Internalized Al, measured by atomic absorption spectrometry, was linearly proportional to the extracellular Al concentration. Northern blot analyses showed thatcytochrome c oxidase subunit III (COX III) mRNA was significantly reduced by 70% after addition of 1 muM AlCl3. Higher concentrations of AlCl3 did not show a significant further effect. These results suggest that Al neurotoxicity involves a specific impairment of cytochrome c oxidase. NeuroReport 12:721-724 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:10:49