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Titolo:
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells
Autore:
Soga, TM; Nakayama, T; Inoue, N;
Indirizzi:
Yokohama City Univ, Sch Med, Dept Biochem 1, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 829 - 832
SICI:
0959-4965(20010326)12:4<829:EARONP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA,K-ATPASE ALPHA-SUBUNITS; GLUTAMATE RECEPTORS; CEREBRAL NEURONS; RAT CEREBELLUM; BETA-SUBUNITS; NA+,K+-ATPASE; ACTIVATION; SECRETION; INVITRO; ATPASE;
Keywords:
cerebellar granule neurons; glutamate; K+ uptake; Na,K-ATPase isozymes; Na,K pump; neuronal excitation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, N Yokohama City Univ, Sch Med, Dept Biochem 1, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 360004, Japan
Citazione:
T.M. Soga et al., "Expression and regulation of Na pump isoforms in cultured cerebellar granule cells", NEUROREPORT, 12(4), 2001, pp. 829-832

Abstract

We investigated expression of Na pump isoforms in cultured cerebellar granule cells and measured in situ ion pump activities of the isoforms, to elucidate functions of Na pump isoforms in neurons. The cells expressed three Na pump isoforms (alpha1, alpha2 and alpha3 isoforms), however the alpha1 isoform acted as a main ion pump ender basal conditions. The ion pump activity of the alpha3/alpha2 isoforms increased remarkably after stimulation of the neurons with glutamate, therefore the alpha3/alpha2 isoforms as well as the alpha1 isoform acted as ion pumps after the stimulation. The glutamate effects were mainly mediated by non-NMDA receptors. These results suggest that alpha1 isoform and alpha3/alpha2 isoforms are functionally important under basal conditions and after neuronal excitation, respectively. NeuroReport 12:829-832 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:36:48