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Titolo:
Extension of glial processes by activation of Ca2+-permeable AMPA receptorchannels
Autore:
Ishiuchi, S; Tsuzuki, K; Yamada, N; Okado, H; Miwa, A; Kuromi, H; Yokoo, H; Nakazato, Y; Sasaki, T; Ozawa, S;
Indirizzi:
Gunma Univ, Sch Med, Dept Neurol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Dept Physiol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Dept Pathol, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 l, Maebashi, Gumma 3718511, Japan Gunma Univ, Sch Med, Inst Behav Sci, Maebashi, Gumma 3718511, Japan Gunma Univ Maebashi Gumma Japan 3718511 i, Maebashi, Gumma 3718511, Japan Tokyo Metropolitan Inst Neurosci, Dept Neurobiol, Fuchu, Tokyo 1838526, Japan Tokyo Metropolitan Inst Neurosci Fuchu Tokyo Japan 1838526 1838526, Japan Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan Japan Sci & Technol Corp Kawaguchi Saitama Japan 3320012 a 3320012, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 745 - 748
SICI:
0959-4965(20010326)12:4<745:EOGPBA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTORS; KAINATE RECEPTORS; KINASE-II; CELLS; PROTEIN; PERMEABILITY; EXPRESSION; ASTROCYTES; VIMENTIN; ENTRY;
Keywords:
adenoviral vector; AMPA receptor; Bergmann glia; Ca2+; GluR2; glutamate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiuchi, S Gunma Univ, Sch Med, Dept Neurol, 3-39-22 Showa-machi, Maebashi, Gumma 3718511, Japan Gunma Univ 3-39-22 Showa-machi Maebashi Gumma Japan3718511 an
Citazione:
S. Ishiuchi et al., "Extension of glial processes by activation of Ca2+-permeable AMPA receptorchannels", NEUROREPORT, 12(4), 2001, pp. 745-748

Abstract

AMPA type-glutamate receptor channels (AMPARs) assembled without the GluR2(GluR-B) subunit are characterized by high Ca2+ permeability, and are expressed abundantly in cerebellar Bergmann glial cells. Here we show that the morphology of cultured Bergmann glia-like fusiform cells derived from the rat cerebellum was changed by manipulating expression of Ca2+-permeable AMPARs using adenoviral vector-mediated gene transfer. Converting endogenous Ca2+-permeable AMPARs into Ca2+-impermeable channels by viral-mediated transfer of GluR2 gene induced retraction of glial processes. In contrast, overexpression of Ca2+-permeable AMPARs markedly elongated glial processes. The process extension was blocked by 2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX), a specific antagonist of AMPAR. These results indicate that lates the morphology of glial processes by glutamate-permeable AMPARs. NeuroReport 12:745-748 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 03/04/20 alle ore 10:54:06