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Titolo:
N- and L- but not P/Q-type calcium channels contribute to neuropeptide release from rat skin in vitro
Autore:
Kress, M; Izydorczyk, I; Kuhn, A;
Indirizzi:
Univ Erlangen Nurnberg, Inst Physiol & Expt Pathophysiol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 867 - 870
SICI:
0959-4965(20010326)12:4<867:NALBNP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; NEUROGENIC PLASMA EXTRAVASATION; CALCITONIN-GENE; SUBSTANCE-P; ELECTRICAL-STIMULATION; ANTAGONIST; NERVE; NEURONS; CGRP; INFLAMMATION;
Keywords:
calcium channel; calcium-dependent; CGRP; exocytosis; flare reaction; neuropeptides; nociceptor; voltage operated;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kress, M Univ Erlangen Nurnberg, Inst Physiol & Expt Pathophysiol, Univ Str 17, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Univ Str 17 Erlangen Germany D-91054 many
Citazione:
M. Kress et al., "N- and L- but not P/Q-type calcium channels contribute to neuropeptide release from rat skin in vitro", NEUROREPORT, 12(4), 2001, pp. 867-870

Abstract

Here we directly demonstrate the liberation of CGRP from rat skin in vitroinduced by high extracellular concentrations of KCl. The EC50 was 52 mM KCl and saturation was reached from 80 mM KCl. The release was entirely dependent on the presence of extracellular calcium ions. It was reduced by non-subtype selective inhibition of voltage-operated calcium channels (VOCCs). Application of selective antagonists suggest expression of L-type and N-typebut not P/Q-type VOCCs in cutaneous nociceptive terminals. These may be activated by any suprathreshold depolarizing stimuli to induce neurogenic inflammation. The expression pattern greatly differs from central nociceptive terminals where, in addition, P/Q-type VOCC have been found. NeuroReport 12:867-870 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 08:21:20