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Titolo:
Modulation of P-CREB and expression of c-Fos in cochlear nucleus and superior olive following electrical intracochlear stimulation
Autore:
Illing, RB; Michler, SA;
Indirizzi:
Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, D-79106 Freiburg,Germany Univ Freiburg Freiburg Germany D-79106 Res Lab, D-79106 Freiburg,Germany
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 875 - 878
SICI:
0959-4965(20010326)12:4<875:MOPAEO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; MESSENGER-RNA EXPRESSION; ADULT-RAT; IMMUNOREACTIVITY; PLASTICITY; NEURONS; PATHWAY; GAP-43; ELEMENT; AP-1;
Keywords:
auditory brain stem; cochlear implant; cochlear nucleus; CREB; c-Fos; P-CREB; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Illing, RB Univ Freiburg, Dept Otorhinolaryngol, Neurobiol Res Lab, Killianstr 5, D-79106 Freiburg, Germany Univ Freiburg Killianstr 5 Freiburg Germany D-79106 g, Germany
Citazione:
R.B. Illing e S.A. Michler, "Modulation of P-CREB and expression of c-Fos in cochlear nucleus and superior olive following electrical intracochlear stimulation", NEUROREPORT, 12(4), 2001, pp. 875-878

Abstract

Investigating activity-dependent plasticity in the auditory brain stem of the adult rat, we observed that electrical intracochlear stimulation led toa tonotopically localized modulation of the phosphorylation of the cAMP response element binding protein (CREB) and an equally localized expression of the immediate early gene product c-Fos in cochlear nucleus and superior olive. As P-CREB is thought to act as transcription factor on one promoter site of the c-fos gene, we compared immunolabeling for P-CREB and c-fos in adjacent brain sections. Following 2 h sustained stimulation in previously deafened animals, labelling for P-CREB declined in regions where c-Fos labelling increased. This suggests that the level or state of P-CREB (e.g. whether it is phosphorylated or not) are affected by intracochlear stimulation in a process that appears to be linked to the stimulation-dependent expression of c-Fos in auditory brain stem nuclei. NeuroReport 12:875-878 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 30/05/20 alle ore 15:01:09