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Titolo:
Dopamine modulates sodium currents in cochlear spiral ganglion neurons
Autore:
Sun, W; Salvi, RJ;
Indirizzi:
SUNY Buffalo, Hearing Res Lab, Buffalo, NY 14214 USA SUNY Buffalo BuffaloNY USA 14214 Hearing Res Lab, Buffalo, NY 14214 USA
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 12, anno: 2001,
pagine: 803 - 807
SICI:
0959-4965(20010326)12:4<803:DMSCIC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; RAT;
Keywords:
D1 and D2 receptor; dopamine; sodium channel; spiral ganglion; whole-cell recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Salvi, RJ SUNY Buffalo, Hearing Res Lab, 215 Parker Hall, Buffalo, NY 14214 USA SUNY Buffalo 215 Parker Hall Buffalo NY USA 14214 , NY 14214 USA
Citazione:
W. Sun e R.J. Salvi, "Dopamine modulates sodium currents in cochlear spiral ganglion neurons", NEUROREPORT, 12(4), 2001, pp. 803-807

Abstract

Lateral olivocochlear (LOC) efferent neurons, putatively dopaminergic, synapse on afferent dendrites of type I spiral ganglion neurons (SGNs) in the cochlea and depress their activity. To investigate the underlying mechanisms, whole-cell patch clamp recordings were obtained from mouse SGNs. Dopamine (DA), and D1-like (D1, D5) and D2-like (D2, D3 and D4) receptor agonists,reduced AP amplitude and induced a slow transient depolarization. Under voltage clamp, D1-like and D2-like agonists induced a dose-dependent inward current that was reversibly blocked by their receptor antagonists. The inward current was blocked by tetrodotoxin (TTX), implicating Na+ channels. The reduction of AP amplitude and voltage-gated Na+ current by DA and DA agonists provides a mechanism for suppressing spike activity in type I afferent neurons. NeuroReport 12:803-807 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:40:10